Daniel Cameron Thompson, M S Bailey, D Bowley, S Jacob
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引用次数: 2
摘要
一名34岁女兵在肯尼亚部署期间出现发烧和行为改变,并被诊断患有脑炎。患者被紧急空运后送至伯明翰伊丽莎白女王医院接受进一步治疗。微生物试验排除了东非地区流行的常见传染原因。然而,自身抗体筛选对n -甲基- d -天冬氨酸受体(NMDAR)抗体呈阳性。全身成像证实边缘脑炎和卵巢肿块提示畸胎瘤的存在。患者被诊断为卵巢畸胎瘤相关的抗nmdar脑炎,这是一种潜在的致命疾病。患者接受手术切除畸胎瘤,并开始使用类固醇、血浆置换和利妥昔单抗进行免疫治疗。这一病例突出了在热带环境中部署的军事人员发热伴行为改变的诊断挑战。
Encephalitis on deployment in Kenya: think beyond the infections.
A 34-year-old female soldier presented with fever and behavioural changes while deployed in Kenya and was diagnosed with encephalitis. The patient underwent urgent aeromedical evacuation to the Queen Elizabeth Hospital, Birmingham for further management. Microbiology tests excluded common infectious causes that are endemic in the East Africa region. However, an autoantibody screen was positive for antibodies against the N-methyl-D-aspartate receptor (NMDAR). Full body imaging confirmed the presence of limbic encephalitis and an ovarian mass suggestive of a teratoma. The patient was diagnosed with ovarian teratoma-associated anti-NMDAR encephalitis, a potentially fatal disease. The patient underwent surgery to remove the teratoma and commenced immunotherapy with steroids, plasma exchange and rituximab. This case highlights the diagnostic challenges of fever with behavioural changes in military personnel deployed in a tropical environment.
期刊介绍:
The Journal of the Royal Army Medical Corps aims to publish high quality research, reviews and case reports, as well as other invited articles, which pertain to the practice of military medicine in its broadest sense. It welcomes material from all ranks, services and corps wherever they serve as well as submissions from beyond the military. It is intended not only to propagate current knowledge and expertise but also to act as an institutional memory for the practice of medicine within the military.