健康和非传染性疾病的医学概况。

Q2 Biochemistry, Genetics and Molecular Biology High-Throughput Pub Date : 2019-04-23 DOI:10.3390/ht8020010

Clara Gonçalves-Dias, Judit Morello, Valdir Semedo, M João Correia, Nuno R Coelho, Emilia C Monteiro, Alexandra M M Antunes, Sofia A Pereira

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引用次数: 7

摘要

巯基酸途径是一种独特的代谢回路，通过与谷胱甘肽形成加合物来解毒亲电试剂。自一个多世纪前汞捕获途径被发现以来，大多数关于汞捕获途径的知识都来自于环境暴露于毒物的生物监测研究。然而，在人类健康和疾病中形成的与汞捕获途径相关的代谢物-汞捕获谱尚未确定。在本文中，我们提出这些代谢物是非传染性慢性炎症性疾病发生发展背后的关键病理生理因素的假设。本文综述了内源性代谢物通过汞捕获途径形成的证据，以及它们的评估方法及其与癌症、呼吸系统、神经系统和心脏代谢疾病的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The mercapturomic profile of health and non-communicable diseases.

The mercapturate pathway is a unique metabolic circuitry that detoxifies electrophiles upon adducts formation with glutathione. Since its discovery over a century ago, most of the knowledge on the mercapturate pathway has been provided from biomonitoring studies on environmental exposure to toxicants. However, the mercapturate pathway-related metabolites that is formed in humans-the mercapturomic profile-in health and disease is yet to be established. In this paper, we put forward the hypothesis that these metabolites are key pathophysiologic factors behind the onset and development of non-communicable chronic inflammatory diseases. This review goes from the evidence in the formation of endogenous metabolites undergoing the mercapturate pathway to the methodologies for their assessment and their association with cancer and respiratory, neurologic and cardiometabolic diseases.

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来源期刊

High-Throughput Biochemistry, Genetics and Molecular Biology-Biotechnology

CiteScore

3.60

自引率

0.00%

发文量

审稿时长

9 weeks

期刊介绍： High-Throughput (formerly Microarrays, ISSN 2076-3905) is a multidisciplinary peer-reviewed scientific journal that provides an advanced forum for the publication of studies reporting high-dimensional approaches and developments in Life Sciences, Chemistry and related fields. Our aim is to encourage scientists to publish their experimental and theoretical results based on high-throughput techniques as well as computational and statistical tools for data analysis and interpretation. The full experimental or methodological details must be provided so that the results can be reproduced. There is no restriction on the length of the papers. High-Throughput invites submissions covering several topics, including, but not limited to: -Microarrays -DNA Sequencing -RNA Sequencing -Protein Identification and Quantification -Cell-based Approaches -Omics Technologies -Imaging -Bioinformatics -Computational Biology/Chemistry -Statistics -Integrative Omics -Drug Discovery and Development -Microfluidics -Lab-on-a-chip -Data Mining -Databases -Multiplex Assays