颈动脉内膜-中膜厚度:慢性肾病患者心血管疾病的替代标志物

IF 2.3 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Clinical Medicine Insights. Cardiology Pub Date : 2019-06-21 eCollection Date: 2019-01-01 DOI:10.1177/1179546819852941
Olutoyin Morenike Lawal, Michael Olabode Balogun, Anthony Olubunmi Akintomide, Oluwagbemiga Oluwole Ayoola, Tuoyo Omasan Mene-Afejuku, Oluwadare Ogunlade, Oluyomi Oluseun Okunola, Adekunle Oyeyemi Lawal, Adewale Akinsola
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引用次数: 11

摘要

背景:心血管疾病(CVD)是慢性肾脏疾病(CKD)患者死亡的主要原因。颈动脉内膜-中膜厚度(CIMT)是衡量动脉粥样硬化性血管疾病的指标,被认为是多种心血管危险因素随时间对动脉壁造成的所有改变的全面描述。因此,我们试图确定CKD患者颈总动脉的CIMT,并评估CKD患者CVD的临床模式和患病率。方法:一项病例对照研究,涉及100名受试者,其中50名CKD 2至4期患者,50名年龄和性别明显正常的个体。如果测量到颈总动脉内膜-中膜厚度大于0.8 mm,则认为颈总动脉增厚。所有受试者均进行了实验室检查、12导联心电图、经胸超声心动图和踝肱指数。结果:CKD人群的平均CIMT高于对照组(P P结论:由于CIMT与CKD患者中许多心血管危险因素密切相关,因此它可能作为CVD的替代标志物,其早期评估可能针对可能需要更积极治疗的患者,以延缓肾脏疾病的进展并改善预后。
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Carotid Intima-Media Thickness: A Surrogate Marker for Cardiovascular Disease in Chronic Kidney Disease Patients.

Background: Cardiovascular disease (CVD) is the leading cause of mortality in patients with chronic kidney disease (CKD). Carotid intima-media thickness (CIMT) is a measure of atherosclerotic vascular disease and considered a comprehensive picture of all alterations caused by multiple cardiovascular risk factors over time on the arterial walls. We therefore sought to determine the CIMT of the common carotid artery in patients with CKD and to evaluate the clinical pattern and prevalence of CVD in CKD patients.

Methods: A case-control study involving 100 subjects made of 50 patients with CKD stages 2 to 4 and 50 age and sex matched apparently normal individuals. Carotid intima-media thickness of the common carotid artery was considered thickened if it measured greater than 0.8 mm. All subjects had laboratory investigations, 12-lead electrocardiogram, transthoracic echocardiography, and ankle-brachial index.

Results: The mean CIMT was higher in CKD population compared with controls (P < .001). Eighty-four percent of the study population was found to have thickened CIMT compared with 18% of controls (P < .001). Patients with CKD had significantly higher blood pressure and heart rate than controls. Cardiovascular disease was also more prevalent among patients with CKD as compared with controls. Carotid intima-media thickness positively correlated with age, blood pressure, and random blood sugar.

Conclusions: As CIMT was well correlated with many cardiovascular risk factors among CKD patients, it may serve as a surrogate marker for CVD and its early assessment may target patients who may need more aggressive therapy to retard the progression of kidney disease and improve outcome.

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来源期刊
Clinical Medicine Insights. Cardiology
Clinical Medicine Insights. Cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
5.20
自引率
3.30%
发文量
16
审稿时长
8 weeks
期刊最新文献
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