{"title":"人类多能干细胞中被抑制的x染色体:抑制还是消除x上调?","authors":"Harman Kaur, Pavithra Rv, Srimonta Gayen","doi":"10.1007/s00412-019-00717-5","DOIUrl":null,"url":null,"abstract":"<p><p>The recent report of X-chromosome dampening in human preimplantation embryos remains controversial. Subsequently, Sahakyan et al. found evidence of X-chromosome dampening in human naïve pluripotent stem cells (hPSCs) as well. Here, we discuss whether X-dampening reported in hPSCs truly reflects the dampening of X-chromosomes or it is a consequence of the erasure of X-chromosome upregulation.</p>","PeriodicalId":10248,"journal":{"name":"Chromosoma","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00412-019-00717-5","citationCount":"7","resultStr":"{\"title\":\"Dampened X-chromosomes in human pluripotent stem cells: dampening or erasure of X-upregulation?\",\"authors\":\"Harman Kaur, Pavithra Rv, Srimonta Gayen\",\"doi\":\"10.1007/s00412-019-00717-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The recent report of X-chromosome dampening in human preimplantation embryos remains controversial. Subsequently, Sahakyan et al. found evidence of X-chromosome dampening in human naïve pluripotent stem cells (hPSCs) as well. Here, we discuss whether X-dampening reported in hPSCs truly reflects the dampening of X-chromosomes or it is a consequence of the erasure of X-chromosome upregulation.</p>\",\"PeriodicalId\":10248,\"journal\":{\"name\":\"Chromosoma\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2020-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1007/s00412-019-00717-5\",\"citationCount\":\"7\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chromosoma\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1007/s00412-019-00717-5\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2019/7/4 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chromosoma","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1007/s00412-019-00717-5","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2019/7/4 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Dampened X-chromosomes in human pluripotent stem cells: dampening or erasure of X-upregulation?
The recent report of X-chromosome dampening in human preimplantation embryos remains controversial. Subsequently, Sahakyan et al. found evidence of X-chromosome dampening in human naïve pluripotent stem cells (hPSCs) as well. Here, we discuss whether X-dampening reported in hPSCs truly reflects the dampening of X-chromosomes or it is a consequence of the erasure of X-chromosome upregulation.
期刊介绍：
Chromosoma publishes research and review articles on the functional organization of the eukaryotic cell nucleus, with a particular emphasis on the structure and dynamics of chromatin and chromosomes; the expression and replication of genomes; genome organization and evolution; the segregation of genomes during meiosis and mitosis; the function and dynamics of subnuclear compartments; the nuclear envelope and nucleocytoplasmic interactions, and more.
The scope of Chromosoma encompasses genetic, biophysical, molecular and cell biological studies.
Average time from receipt of contributions to first decision: 22 days
Publishes research and review articles on the functional organization of the eukaryotic cell nucleus
Topics include structure and dynamics of chromatin and chromosomes; the expression and replication of genomes; genome organization and evolution; the segregation of genomes during meiosis and mitosis and more
Encompasses genetic, biophysical, molecular and cell biological studies.
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