Izabela Wojtkowska, Tomasz A Bonda, Andrzej Tysarowski, Katarzyna Seliga, Janusz A Siedlecki, Maria M Winnicka, Janina Stępińska
{"title":"PPARG2 Pro12Ala和TNFα -308G>A多态性与缺血性心脏病患者冠状动脉搭桥术后心力衰竭的发生无关","authors":"Izabela Wojtkowska, Tomasz A Bonda, Andrzej Tysarowski, Katarzyna Seliga, Janusz A Siedlecki, Maria M Winnicka, Janina Stępińska","doi":"10.1155/2019/1932036","DOIUrl":null,"url":null,"abstract":"<p><p>TNF<i>α</i> and PPAR<i>γ</i> are important modulators of metabolism, inflammation, and atherosclerosis. Coronary artery disease is the leading cause of heart failure (HF). The aim of the study was to assess whether polymorphisms of the <i>TNFα</i> (-308G>A) and <i>PPARG2</i> (Pro12Ala) genes are associated with the risk of developing HF by patients with ischemic heart disease. <i>Methods</i>. 122 patients without HF (aged 63 ± 8.8 years, 85% males) with confirmed coronary artery disease qualified for coronary bypass grafting were enrolled in the study. After the procedure, they were screened for cardiac parameters. Those with elevated NT-proBNP or diminished left ventricular ejection fraction during follow-up were assigned to the HF group (n=78), and the remaining ones to the non-HF group (n=44). The <i>TNFα</i> -308G>A and <i>PPARG</i>2 Pro12Ala polymorphisms were detected using the TaqMan method. <i>Results</i>. The distributions of <i>TNFα</i> -308G>A and <i>PPARG</i>2 Pro12Ala did not differ between the HF and non-HF groups (-308G>A: 16% vs. 11.4% of alleles; Pro12Ala: 23.9% vs. 20.5% of alleles, respectively). IL-6 concentration in the plasma of <i>TNFα</i> A-allele carriers at months 1 and 12 after CABG was higher in the HF group compared to the non-HF group (1 month after CABG: 5.3 ± 3.4 vs. 3.1 ± 2.9, p<0.05; 12 months after CABG: 4.2 ± 3,9 vs. 1.4 ± 1.2, p<0.01, respectively). Both polymorphisms were not related to changes in the plasma TNF<i>α</i> concentration or other parameters related to HF. <i>Conclusions</i>. Our study did not reveal any correlation between the <i>PPARG2</i> Pro12Ala and <i>TNFα</i> -308G>A polymorphisms and development of HF in patients with ischemic heart disease after coronary bypass grafting.</p>","PeriodicalId":20439,"journal":{"name":"PPAR Research","volume":"2019 ","pages":"1932036"},"PeriodicalIF":3.5000,"publicationDate":"2019-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2019/1932036","citationCount":"1","resultStr":"{\"title\":\"PPARG2 Pro12Ala and TNF<i>α</i> -308G>A Polymorphisms Are Not Associated with Heart Failure Development in Patients with Ischemic Heart Disease after Coronary Artery Bypass Grafting.\",\"authors\":\"Izabela Wojtkowska, Tomasz A Bonda, Andrzej Tysarowski, Katarzyna Seliga, Janusz A Siedlecki, Maria M Winnicka, Janina Stępińska\",\"doi\":\"10.1155/2019/1932036\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>TNF<i>α</i> and PPAR<i>γ</i> are important modulators of metabolism, inflammation, and atherosclerosis. Coronary artery disease is the leading cause of heart failure (HF). The aim of the study was to assess whether polymorphisms of the <i>TNFα</i> (-308G>A) and <i>PPARG2</i> (Pro12Ala) genes are associated with the risk of developing HF by patients with ischemic heart disease. <i>Methods</i>. 122 patients without HF (aged 63 ± 8.8 years, 85% males) with confirmed coronary artery disease qualified for coronary bypass grafting were enrolled in the study. After the procedure, they were screened for cardiac parameters. Those with elevated NT-proBNP or diminished left ventricular ejection fraction during follow-up were assigned to the HF group (n=78), and the remaining ones to the non-HF group (n=44). The <i>TNFα</i> -308G>A and <i>PPARG</i>2 Pro12Ala polymorphisms were detected using the TaqMan method. <i>Results</i>. The distributions of <i>TNFα</i> -308G>A and <i>PPARG</i>2 Pro12Ala did not differ between the HF and non-HF groups (-308G>A: 16% vs. 11.4% of alleles; Pro12Ala: 23.9% vs. 20.5% of alleles, respectively). IL-6 concentration in the plasma of <i>TNFα</i> A-allele carriers at months 1 and 12 after CABG was higher in the HF group compared to the non-HF group (1 month after CABG: 5.3 ± 3.4 vs. 3.1 ± 2.9, p<0.05; 12 months after CABG: 4.2 ± 3,9 vs. 1.4 ± 1.2, p<0.01, respectively). Both polymorphisms were not related to changes in the plasma TNF<i>α</i> concentration or other parameters related to HF. <i>Conclusions</i>. Our study did not reveal any correlation between the <i>PPARG2</i> Pro12Ala and <i>TNFα</i> -308G>A polymorphisms and development of HF in patients with ischemic heart disease after coronary bypass grafting.</p>\",\"PeriodicalId\":20439,\"journal\":{\"name\":\"PPAR Research\",\"volume\":\"2019 \",\"pages\":\"1932036\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2019-06-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1155/2019/1932036\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"PPAR Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1155/2019/1932036\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2019/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"PPAR Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1155/2019/1932036","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2019/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 1
摘要
TNFα和PPARγ是代谢、炎症和动脉粥样硬化的重要调节剂。冠状动脉疾病是导致心力衰竭的主要原因。该研究的目的是评估TNFα (-308G>A)和PPARG2 (Pro12Ala)基因多态性是否与缺血性心脏病患者发生HF的风险相关。方法:122例无心衰患者(年龄63±8.8岁,男性85%)经证实有冠状动脉病变,符合冠状动脉搭桥术条件。手术后,他们接受了心脏参数的筛查。随访期间NT-proBNP升高或左室射血分数降低的患者被分配到HF组(n=78),其余患者被分配到非HF组(n=44)。TaqMan法检测TNFα -308G>A和PPARG2 Pro12Ala多态性。结果。TNFα -308G>A和PPARG2 Pro12Ala在HF组和非HF组之间的分布无差异(-308G>A: 16% vs. 11.4%;Pro12Ala: 23.9% vs. 20.5%)。在CABG术后1、12个月,HF组TNFα a等位基因携带者血浆IL-6浓度高于非HF组(CABG术后1个月:5.3±3.4 vs 3.1±2.9),pα浓度或其他与HF相关的参数。结论。我们的研究未发现PPARG2 Pro12Ala和TNFα -308G>A多态性与缺血性心脏病患者冠状动脉搭桥术后HF的发生之间存在相关性。
PPARG2 Pro12Ala and TNFα -308G>A Polymorphisms Are Not Associated with Heart Failure Development in Patients with Ischemic Heart Disease after Coronary Artery Bypass Grafting.
TNFα and PPARγ are important modulators of metabolism, inflammation, and atherosclerosis. Coronary artery disease is the leading cause of heart failure (HF). The aim of the study was to assess whether polymorphisms of the TNFα (-308G>A) and PPARG2 (Pro12Ala) genes are associated with the risk of developing HF by patients with ischemic heart disease. Methods. 122 patients without HF (aged 63 ± 8.8 years, 85% males) with confirmed coronary artery disease qualified for coronary bypass grafting were enrolled in the study. After the procedure, they were screened for cardiac parameters. Those with elevated NT-proBNP or diminished left ventricular ejection fraction during follow-up were assigned to the HF group (n=78), and the remaining ones to the non-HF group (n=44). The TNFα -308G>A and PPARG2 Pro12Ala polymorphisms were detected using the TaqMan method. Results. The distributions of TNFα -308G>A and PPARG2 Pro12Ala did not differ between the HF and non-HF groups (-308G>A: 16% vs. 11.4% of alleles; Pro12Ala: 23.9% vs. 20.5% of alleles, respectively). IL-6 concentration in the plasma of TNFα A-allele carriers at months 1 and 12 after CABG was higher in the HF group compared to the non-HF group (1 month after CABG: 5.3 ± 3.4 vs. 3.1 ± 2.9, p<0.05; 12 months after CABG: 4.2 ± 3,9 vs. 1.4 ± 1.2, p<0.01, respectively). Both polymorphisms were not related to changes in the plasma TNFα concentration or other parameters related to HF. Conclusions. Our study did not reveal any correlation between the PPARG2 Pro12Ala and TNFα -308G>A polymorphisms and development of HF in patients with ischemic heart disease after coronary bypass grafting.
期刊介绍:
PPAR Research is a peer-reviewed, Open Access journal that publishes original research and review articles on advances in basic research focusing on mechanisms involved in the activation of peroxisome proliferator-activated receptors (PPARs), as well as their role in the regulation of cellular differentiation, development, energy homeostasis and metabolic function. The journal also welcomes preclinical and clinical trials of drugs that can modulate PPAR activity, with a view to treating chronic diseases and disorders such as dyslipidemia, diabetes, adipocyte differentiation, inflammation, cancer, lung diseases, neurodegenerative disorders, and obesity.