单壁碳纳米管负载羟基磷灰石-海藻酸盐珠具有增强的机械性能和持续药物释放能力。

IF 4.4 3区 医学 Q2 ENGINEERING, BIOMEDICAL Progress in Biomaterials Pub Date : 2020-06-01 Epub Date: 2020-01-30 DOI:10.1007/s40204-020-00127-2
L B Sukhodub, L F Sukhodub, M O Kumeda, Yu I Prylutskyy, M V Pogorielov, M P Evstigneev, V V Kostjukov, N Y Strutynska, L L Vovchenko, S V Khrapatiy, U Ritter
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引用次数: 10

摘要

合成并研究了具有增强力学性能的生物材料单壁碳纳米管(SWCNTs)在骨科领域的潜在应用。x射线衍射和x射线荧光分析表明,在微波辐照作用下形成了碳酸盐含量低的缺钙羟基磷灰石(Ca/P = 1.65)。研究了SWCNTs负载ha -海藻酸盐复合材料的力学性能(最大相对变形、抗压强度和杨氏模量),证实了它们与SWCNTs含量的关系。ha -海藻酸盐- swcnts和ha -海藻酸盐对照(分别为202和159 MPa)的抗压强度在皮质骨的特征值范围内。与HA含量相比,添加0.5%的单壁碳纳米管可提高HA-海藻酸盐-单壁碳纳米管的杨氏模量(645 MPa),而不添加单壁碳纳米管的HA-海藻酸盐样品的杨氏模量(563 MPa),并增强材料在模拟生理条件下的形状稳定性。对ha -海藻酸盐- swcnts体系的结构建模表明,swcnts对ha -海藻酸盐的物理吸附是通过形成由疏溶剂/范德华相互作用和氢键稳定的三重配合物进行的。高效液相色谱证实了SWCNTs对麻醉药物(用作模型药物)持续释放的影响(456 h,而无SWCNTs的样品为408 h)。细胞培养实验证实了0.05%和0.5%含swcnts的复合材料在3天培养期间的生物相容性和成骨细胞增殖的刺激。所有这些事实可能表明,基于透明质酸和海藻酸盐的含swcnts材料用于骨组织工程的潜在可能性。
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Single-walled carbon nanotubes loaded hydroxyapatite-alginate beads with enhanced mechanical properties and sustained drug release ability.

Single-walled carbon nanotubes (SWCNTs) containing biomaterial with enhanced mechanical properties for the potential orthopedic application were synthesized and investigated. X-ray diffraction and X-ray fluorescence analysis were indications of the formation of calcium-deficient (Ca/P = 1.65) hydroxyapatite (HA) with a small carbonate content under influence of microwave irradiation. The investigated mechanical properties (maximal relative deformation, compressive strength and Young's modulus) of SWCNT loaded HA-alginate composites confirm their dependence on SWCNTs content. The compressive strength of HA-alginate-SWCNT and the HA-alginate control (202 and 159 MPa, respectively) lies within the values characteristic for the cortical bone. The addition of 0.5% SWCNT, in relation to the content of HA, increases the Young's modulus of the HA-alginate-SWCNT (645 MPa) compared to the SWCNT-free HA-alginate sample (563 MPa), and enhances the material shape stability in simulated physiological conditions. Structural modeling of HA-alginate-SWCNT system showed, that physical adsorption of SWCNT into HA-alginate occurs by forming triple complexes stabilized by solvophobic/van der Waals interactions and H-bonds. The high-performance liquid chromatography demonstrated the influence of SWCNTs on the sustained anaesthesinum drug (used as a model drug) release (456 h against 408 h for SWCNT-free sample). Cell culture assay confirmed biocompatibility and stimulation of osteoblast proliferation of 0.05% and 0.5% SWCNT-containing composites during a 3-day cultivation. All these facts may suggest the potential possibility of using the SWCNT-containing materials, based on HA and alginate, for bone tissue engineering.

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来源期刊
Progress in Biomaterials
Progress in Biomaterials MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
9.60
自引率
4.10%
发文量
35
期刊介绍: Progress in Biomaterials is a multidisciplinary, English-language publication of original contributions and reviews concerning studies of the preparation, performance and evaluation of biomaterials; the chemical, physical, biological and mechanical behavior of materials both in vitro and in vivo in areas such as tissue engineering and regenerative medicine, drug delivery and implants where biomaterials play a significant role. Including all areas of: design; preparation; performance and evaluation of nano- and biomaterials in tissue engineering; drug delivery systems; regenerative medicine; implantable medical devices; interaction of cells/stem cells on biomaterials and related applications.
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