通过刺猬通路透镜在初级纤毛中的信号传导。

Q1 Biochemistry, Genetics and Molecular Biology Wiley Interdisciplinary Reviews: Developmental Biology Pub Date : 2020-11-01 Epub Date: 2020-02-21 DOI:10.1002/wdev.377
Eduardo D Gigante, Tamara Caspary
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引用次数: 49

摘要

纤毛是基于微管的细胞表面突起,其机制在进化上是保守的。在脊椎动物中,几乎在每一种细胞类型上都可以观察到纤毛,它们要么是活动的,要么是不活动的。固定感觉纤毛或初级纤毛对细胞外配体和信号有反应。纤毛可以被认为是隔室,在功能上不同于为信号级联提供环境的细胞。Hedgehog基因是脊椎动物重要的发育信号通路,在功能上与初级纤毛相关。脊椎动物Hedgehog信号通路的主要成分动态定位于纤毛室和纤毛膜。关键的是,g蛋白偶联受体(GPCR) Smoothened,该途径的专性传感器,在纤毛中被富集和激活。Smoothened是研究最深入的纤毛受体,许多gpcr定位于纤毛内。了解Smoothened和纤毛之间的联系定义了初级纤毛中GPCR信号的共同特征和区别。本文分类如下:信号通路>全球信号机制>细胞命运信号。
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Signaling in the primary cilium through the lens of the Hedgehog pathway.

Cilia are microtubule-based, cell-surface projections whose machinery is evolutionarily conserved. In vertebrates, cilia are observed on almost every cell type and are either motile or immotile. Immotile sensory, or primary cilia, are responsive to extracellular ligands and signals. Cilia can be thought of as compartments, functionally distinct from the cell that provides an environment for signaling cascades. Hedgehog is a critical developmental signaling pathway which is functionally linked to primary cilia in vertebrates. The major components of the vertebrate Hedgehog signaling pathway dynamically localize to the ciliary compartment and ciliary membrane. Critically, G-protein coupled receptor (GPCR) Smoothened, the obligate transducer of the pathway, is enriched and activated in the cilium. While Smoothened is the most intensely studied ciliary receptor, many GPCRs localize within cilia. Understanding the link between Smoothened and cilia defines common features, and distinctions, of GPCR signaling within the primary cilium. This article is categorized under: Signaling Pathways > Global Signaling Mechanisms Signaling Pathways > Cell Fate Signaling.

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期刊介绍: Developmental biology is concerned with the fundamental question of how a single cell, the fertilized egg, ultimately produces a complex, fully patterned adult organism. This problem is studied on many different biological levels, from the molecular to the organismal. Developed in association with the Society for Developmental Biology, WIREs Developmental Biology will provide a unique interdisciplinary forum dedicated to fostering excellence in research and education and communicating key advances in this important field. The collaborative and integrative ethos of the WIREs model will facilitate connections to related disciplines such as genetics, systems biology, bioengineering, and psychology. The topical coverage of WIREs Developmental Biology includes: Establishment of Spatial and Temporal Patterns; Gene Expression and Transcriptional Hierarchies; Signaling Pathways; Early Embryonic Development; Invertebrate Organogenesis; Vertebrate Organogenesis; Nervous System Development; Birth Defects; Adult Stem Cells, Tissue Renewal and Regeneration; Cell Types and Issues Specific to Plants; Comparative Development and Evolution; and Technologies.
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