硫化氢供体胶束保护心肌细胞免于缺血性细胞死亡†

IF 3.743 Q2 Biochemistry, Genetics and Molecular Biology Molecular BioSystems Pub Date : 2017-06-28 DOI:10.1039/C7MB00191F
T. Takatani-Nakase, M. Katayama, C. Matsui, K. Hanaoka, A. J. van der Vlies, K. Takahashi, I. Nakase and U. Hasegawa
{"title":"硫化氢供体胶束保护心肌细胞免于缺血性细胞死亡†","authors":"T. Takatani-Nakase, M. Katayama, C. Matsui, K. Hanaoka, A. J. van der Vlies, K. Takahashi, I. Nakase and U. Hasegawa","doi":"10.1039/C7MB00191F","DOIUrl":null,"url":null,"abstract":"<p >Hydrogen sulfide, an important gaseous signaling molecule in the human body, is known to protect cardiomyocytes from ischemia, a condition characterized by insufficient oxygen supply to the cells. Here we show that a nanosized H<small><sub>2</sub></small>S donor micelle releases H<small><sub>2</sub></small>S intracellularly and prevents cardiomyocyte apoptosis in an <em>in vitro</em> ischemia model.</p>","PeriodicalId":90,"journal":{"name":"Molecular BioSystems","volume":" 9","pages":" 1705-1708"},"PeriodicalIF":3.7430,"publicationDate":"2017-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1039/C7MB00191F","citationCount":"14","resultStr":"{\"title\":\"Hydrogen sulfide donor micelles protect cardiomyocytes from ischemic cell death†\",\"authors\":\"T. Takatani-Nakase, M. Katayama, C. Matsui, K. Hanaoka, A. J. van der Vlies, K. Takahashi, I. Nakase and U. Hasegawa\",\"doi\":\"10.1039/C7MB00191F\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >Hydrogen sulfide, an important gaseous signaling molecule in the human body, is known to protect cardiomyocytes from ischemia, a condition characterized by insufficient oxygen supply to the cells. Here we show that a nanosized H<small><sub>2</sub></small>S donor micelle releases H<small><sub>2</sub></small>S intracellularly and prevents cardiomyocyte apoptosis in an <em>in vitro</em> ischemia model.</p>\",\"PeriodicalId\":90,\"journal\":{\"name\":\"Molecular BioSystems\",\"volume\":\" 9\",\"pages\":\" 1705-1708\"},\"PeriodicalIF\":3.7430,\"publicationDate\":\"2017-06-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1039/C7MB00191F\",\"citationCount\":\"14\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Molecular BioSystems\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://pubs.rsc.org/en/content/articlelanding/2017/mb/c7mb00191f\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Biochemistry, Genetics and Molecular Biology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular BioSystems","FirstCategoryId":"1085","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2017/mb/c7mb00191f","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 14

摘要

硫化氢是人体中一种重要的气体信号分子,已知可以保护心肌细胞免受缺血,这是一种以细胞氧气供应不足为特征的疾病。在体外缺血模型中,我们展示了纳米级H2S供体胶束在细胞内释放H2S并阻止心肌细胞凋亡。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

摘要图片

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Hydrogen sulfide donor micelles protect cardiomyocytes from ischemic cell death†

Hydrogen sulfide, an important gaseous signaling molecule in the human body, is known to protect cardiomyocytes from ischemia, a condition characterized by insufficient oxygen supply to the cells. Here we show that a nanosized H2S donor micelle releases H2S intracellularly and prevents cardiomyocyte apoptosis in an in vitro ischemia model.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Molecular BioSystems
Molecular BioSystems 生物-生化与分子生物学
CiteScore
2.94
自引率
0.00%
发文量
0
审稿时长
2.6 months
期刊介绍: Molecular Omics publishes molecular level experimental and bioinformatics research in the -omics sciences, including genomics, proteomics, transcriptomics and metabolomics. We will also welcome multidisciplinary papers presenting studies combining different types of omics, or the interface of omics and other fields such as systems biology or chemical biology.
期刊最新文献
Effects of Oxaliplatin on Facial Sensitivity to Cool Temperatures and TRPM8 Expressing Trigeminal Ganglion Neurons in Mice. Correction: Dynamic properties of dipeptidyl peptidase III from Bacteroides thetaiotaomicron and the structural basis for its substrate specificity – a computational study Pharmacology of predatory and defensive venom peptides in cone snails Staphylococcus aureus extracellular vesicles (EVs): surface-binding antagonists of biofilm formation† Mechanism of the formation of the RecA–ssDNA nucleoprotein filament structure: a coarse-grained approach
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1