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引用次数: 0
摘要
治疗性疫苗和广泛中和抗体(bNAbs)是无抗逆转录病毒治疗艾滋病毒的潜在途径。虽然治疗性疫苗能够在分析性治疗中断(ATIs)期间产生病毒载量的短暂减少,但迄今为止还没有一种疫苗能够引起长期缓解。与潜伏期逆转剂和免疫调节剂配对可提高疫苗效力。bnab被认为是在没有抗逆转录病毒治疗的情况下实现持久病毒学控制的一种有希望的方法。抗体的组合对于增加覆盖的总体广度和效力以及防止出现耐药性是必要的。下一代抗体包括工程化的双特异性和三特异性抗体,它们针对2或3个独立的病毒位点。本文基于Magdalena E. Sobieszczyk医学博士、公共卫生硕士在2019年3月于纽约举行的美国国际抗病毒学会(IAS-USA)继续教育项目上的演讲。
Therapeutic HIV vaccines and broadly neutralizing antibodies.
Therapeutic vaccines and broadly neutralizing antibodies (bNAbs) represent potential approaches to antiretroviral-free treatment of HIV. Although therapeutic vaccines have been able to produce transient reductions in viral load during analytic treatment interruptions (ATIs), thus far none has been able to induce long-term remission. Pairing with latency reversal agents and immune modulators may improve vaccine efficacy. The bNAbs are investigated as a promising approach to achieving durable virologic control in the absence of antiretroviral therapy. Combinations of antibodies are necessary for increasing overall breadth and potency of coverage and preventing emergence of resistance. The next generation of antibodies includes engineered bispecific and trispecific antibodies that target 2 or 3 independent viral sites. This article is based on a presentation by Magdalena E. Sobieszczyk, MD, MPH, at the International Antiviral Society-USA (IAS-USA) continuing education program held in New York in March 2019.