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引用次数: 0

摘要

在血液学治疗程序中,干细胞移植(SCT)是最广泛和最具侵入性的干预措施。在移植的不同阶段,患者都有可能受到多种细菌、病毒和真菌感染。特别是在异基因移植中,鉴别非感染性并发症(主要是免疫性并发症),如移植物抗宿主反应或静脉闭塞症(VOD)至关重要,通常也是治疗上的一大挑战。只有了解 SCT 的特殊并发症,才能对这些患者进行适当的重症监护治疗。本综述首先概述了干细胞移植的各个阶段及其相应的感染性和非感染性并发症,随后讨论了干细胞移植的肺部、肾脏、心脏、胃肠道、肝脏和神经系统并发症。
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[Intensive care support of patients after stem cell transplantation].

Within the hematologic therapy procedures, stem cell transplantation (SCT) represents the most extensive and invasive intervention. Those patients have certain risks for several bacterial, viral, as well as fungal infections during the different stages of transplantation. Especially in allogenic transplantation, discrimination of non-infectious, mostly immunologic complications like graft-versus-host reactions or VOD (veno-occlusive disease) is crucial, and often represents a therapeutic challenge. An adequate intensive care therapy of these patients can only be achieved with the knowledge of the specific complications of SCT. This review starts with an overview of the SCT stages with their corresponding infectious and noninfectious complications, followed by the discussion of organ specific pulmonary, renal, cardiac, gastrointestinal, hepatic and neurological complications of stem cell transplantation.

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