Jacek M Witkowski, Anis Larbi, Aurélie Le Page, Tamàs Fülöp
{"title":"自然杀伤细胞、衰老和疫苗接种。","authors":"Jacek M Witkowski, Anis Larbi, Aurélie Le Page, Tamàs Fülöp","doi":"10.1159/000504493","DOIUrl":null,"url":null,"abstract":"<p><p>Aging is associated with changes in the immune system. Both (innate and adaptive) arms of the immune system are involved. Natural killer (NK) cells are part of the innate immune system. They participate in host defense by eliminating cells that are virally infected, transformed, or senescent. They are also able to modulate the adaptive part of the immune system. As all cells, NK cells are subjected to changes with aging, which affects both their phenotype and functions. Aging is associated with various latent chronic viral infections, and the most significant among them is CMV. It is difficult to distinguish between the influence of CMV infection and that of aging itself on the NK cell properties. Recently, NK cells have been shown to be an important player in vaccine efficacy, which is also decreased with aging. In this chapter, we describe age-related changes in NK cells and their possible influence on the efficacy of vaccination in old age.</p>","PeriodicalId":37866,"journal":{"name":"Interdisciplinary topics in gerontology and geriatrics","volume":"43 ","pages":"18-35"},"PeriodicalIF":0.0000,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000504493","citationCount":"16","resultStr":"{\"title\":\"Natural Killer Cells, Aging, and Vaccination.\",\"authors\":\"Jacek M Witkowski, Anis Larbi, Aurélie Le Page, Tamàs Fülöp\",\"doi\":\"10.1159/000504493\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Aging is associated with changes in the immune system. Both (innate and adaptive) arms of the immune system are involved. Natural killer (NK) cells are part of the innate immune system. They participate in host defense by eliminating cells that are virally infected, transformed, or senescent. They are also able to modulate the adaptive part of the immune system. As all cells, NK cells are subjected to changes with aging, which affects both their phenotype and functions. Aging is associated with various latent chronic viral infections, and the most significant among them is CMV. It is difficult to distinguish between the influence of CMV infection and that of aging itself on the NK cell properties. Recently, NK cells have been shown to be an important player in vaccine efficacy, which is also decreased with aging. In this chapter, we describe age-related changes in NK cells and their possible influence on the efficacy of vaccination in old age.</p>\",\"PeriodicalId\":37866,\"journal\":{\"name\":\"Interdisciplinary topics in gerontology and geriatrics\",\"volume\":\"43 \",\"pages\":\"18-35\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1159/000504493\",\"citationCount\":\"16\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Interdisciplinary topics in gerontology and geriatrics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1159/000504493\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2020/4/9 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Interdisciplinary topics in gerontology and geriatrics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000504493","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2020/4/9 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
Aging is associated with changes in the immune system. Both (innate and adaptive) arms of the immune system are involved. Natural killer (NK) cells are part of the innate immune system. They participate in host defense by eliminating cells that are virally infected, transformed, or senescent. They are also able to modulate the adaptive part of the immune system. As all cells, NK cells are subjected to changes with aging, which affects both their phenotype and functions. Aging is associated with various latent chronic viral infections, and the most significant among them is CMV. It is difficult to distinguish between the influence of CMV infection and that of aging itself on the NK cell properties. Recently, NK cells have been shown to be an important player in vaccine efficacy, which is also decreased with aging. In this chapter, we describe age-related changes in NK cells and their possible influence on the efficacy of vaccination in old age.
期刊介绍：
At a time when interest in the process of aging is driving more and more research, ''Interdisciplinary Topics in Gerontology and Geriatrics'' offers investigators a way to stay at the forefront of developments. This series represents a comprehensive and integrated approach to the problems of aging and presents pertinent data from studies in animal and human gerontology. In order to provide a forum for a unified concept of gerontology, both the biological foundations and the clinical and sociological consequences of aging in humans are presented. Individual volumes are characterized by an analytic overall view of the aging process, novel ideas, and original approaches to healthy aging as well as age-related functional decline.
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