Erhan Aysan, Fikrettin Sahin, Ruzgar Catal, Mirkhaliq Javadov, Alev Cumbul
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引用次数: 2
摘要
背景:腹膜术后粘连(PPA)是腹膜外科手术的一个严重问题。目前还没有找到有效的补救办法。甘油和五硼酸钠的新配方也许能解决这个问题。方法:将雌性Wistar白化大鼠随机分为4组。在盲肠前壁建立粘连模型，各组分别用2 ml 0.9% NaCl、3%甘油、3%五硼酸钠、3%甘油+ 3%五硼酸钠溶液覆盖。两周后，这些老鼠被处死。对PPA进行宏观和微观分级。结果:3%甘油+ 3%五硼酸钠组的总黏附评分与其他组在宏观和微观评价上均有统计学差异(p < 0.001)。结论:3%甘油加3%五硼酸钠新剂型对PPA具有协同预防作用。
Effects of Glycerol and Sodium Pentaborate Formulation on Prevention of Postoperative Peritoneal Adhesion Formation.
Background: Postoperative peritoneal adhesions (PPA) are a serious problem for abdominal surgery. An effective remedy has not been found yet. New formulation of glycerol and sodium pentaborate may be able to solve the problem.
Method: Female Wistar albino rats were randomly assigned into four equal groups. The adhesion model was created on the caecum anterior wall and covered with 2 ml 0.9% NaCl, 3% glycerol, 3% sodium pentaborate, and 3% glycerol plus 3% sodium pentaborate solutions in the groups, respectively. Two weeks later, the rats were sacrificed. PPA were graded macroscopically and microscopically.
Results: Total adhesion scores of the 3% glycerol + 3% sodium pentaborate group were statistically different from the other groups for macroscopic and also microscopic evaluations (p < 0.001).
Conclusion: 3% glycerol plus 3% sodium pentaborate as a new formulation has preventive effects on PPA with a synergistic mechanism.
期刊介绍：
Obstetrics and Gynecology International is a peer-reviewed, Open Access journal that aims to provide a forum for scientists and clinical professionals working in obstetrics and gynecology. The journal publishes original research articles, review articles, and clinical studies related to obstetrics, maternal-fetal medicine, general gynecology, gynecologic oncology, uro-gynecology, reproductive medicine and infertility, reproductive endocrinology, and sexual medicine.
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