肺癌的预处理营养状况和对检查点抑制剂的反应。

Pub Date : 2020-04-24 DOI:10.2217/lmt-2020-0008

Chung-Shien Lee, Craig E Devoe, Xinhua Zhu, Joanna Stein Fishbein, Nagashree Seetharamu

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引用次数: 17

摘要

背景:检查点抑制剂是治疗非小细胞肺癌不可或缺的药物。现有数据表明，营养状况可能在抗肿瘤免疫中发挥作用。材料与方法:这项回顾性研究纳入了2014年至2017年在我院接受检查点抑制剂治疗的106例非小细胞肺癌患者，评估了营养参数与总生存期(OS)和无进展生存期的关系。结果:患者平均年龄68.7±9.2岁，男性占59.4%。在OS的多变量分析中，低白蛋白血症和显著体重减轻是预后因素，p值分别为0.0005和0.0052。我们注意到年龄和OS之间呈抛物线关系(p = 0.026, 0.0025)。结论:在我们的研究中，一些营养不良参数与OS降低有关。年龄与OS之间的u型关系值得进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Pretreatment nutritional status and response to checkpoint inhibitors in lung cancer.

Background: Checkpoint inhibitors are integral to non-small-cell lung cancer treatment. Existing data suggests that nutritional status may play a role in antitumor immunity.

Materials & methods: This retrospective study of 106 non-small-cell lung cancer patients who started checkpoint inhibitors between 2014 and 2017 at our institution assessed relationship of nutritional parameters to overall survival (OS) and progression-free survival.

Results: Mean age was 68.7 ± 9.2 years and 59.4% patients were male. On multivariate analysis for OS, hypoalbuminemia and significant weight loss were prognostic at p-values of 0.0005 and 0.0052, respectively. We noted a parabolic association between age and OS (p = 0.026, 0.0025).

Conclusion: In our study, some malnutrition parameters were associated with decreased OS. U-shape relationship between age and OS noted here warrants further evaluation.

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