Wenfei Huang, Erika P Penaherrera, Danaika F Desir, Dominick L Gamarro, Jessica Cottrell, Tinchun Chu, Sulie L Chang
{"title":"酒精使用和阿片类药物使用障碍双向加速。","authors":"Wenfei Huang, Erika P Penaherrera, Danaika F Desir, Dominick L Gamarro, Jessica Cottrell, Tinchun Chu, Sulie L Chang","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Alcohol is the most widely used addictive substance. Severe alcohol abuse is diagnosed as \"alcohol use disorder\" (AUD). A common and harmful drinking pattern is binge drinking that elevates a person's blood alcohol concentration to ≥ 0.08%. Such drinking may be an early indicator of AUD. Opioid misuse and dependence have become worldwide crises. Patterned consumption of various opioids can develop into opioid use disorder (OUD). An intertwined epidemic exists between opioid abuse, alcohol addiction, and binge drinking. Currently, studies on the interaction of AUD and OUD are limited and the underlying mechanisms linking these disorders remains unclear. We reviewed studies on AUD and OUD and utilized Ingenuity Pathway Analysis (IPA) to identify mechanisms of AUD and OUD interaction and potential gene targets for therapeutic agents. According to IPA Canonical Pathways Analysis, Gamma-aminobutyric Acid (GABA) Receptor Signaling, Neuroinflammation Signaling Pathway, Opioid Signaling Pathway and Dopamine-DARPP32 Feedback in cAMP Signaling are potential contributors to the interaction of AUD and OUD.</p>","PeriodicalId":37818,"journal":{"name":"Journal of Drug and Alcohol Research","volume":"2019 ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241514/pdf/","citationCount":"0","resultStr":"{\"title\":\"Bi-directional Acceleration of Alcohol Use and Opioid Use Disorder.\",\"authors\":\"Wenfei Huang, Erika P Penaherrera, Danaika F Desir, Dominick L Gamarro, Jessica Cottrell, Tinchun Chu, Sulie L Chang\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Alcohol is the most widely used addictive substance. Severe alcohol abuse is diagnosed as \\\"alcohol use disorder\\\" (AUD). A common and harmful drinking pattern is binge drinking that elevates a person's blood alcohol concentration to ≥ 0.08%. Such drinking may be an early indicator of AUD. Opioid misuse and dependence have become worldwide crises. Patterned consumption of various opioids can develop into opioid use disorder (OUD). An intertwined epidemic exists between opioid abuse, alcohol addiction, and binge drinking. Currently, studies on the interaction of AUD and OUD are limited and the underlying mechanisms linking these disorders remains unclear. We reviewed studies on AUD and OUD and utilized Ingenuity Pathway Analysis (IPA) to identify mechanisms of AUD and OUD interaction and potential gene targets for therapeutic agents. According to IPA Canonical Pathways Analysis, Gamma-aminobutyric Acid (GABA) Receptor Signaling, Neuroinflammation Signaling Pathway, Opioid Signaling Pathway and Dopamine-DARPP32 Feedback in cAMP Signaling are potential contributors to the interaction of AUD and OUD.</p>\",\"PeriodicalId\":37818,\"journal\":{\"name\":\"Journal of Drug and Alcohol Research\",\"volume\":\"2019 \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-10-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241514/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Drug and Alcohol Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Psychology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Drug and Alcohol Research","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Psychology","Score":null,"Total":0}
Bi-directional Acceleration of Alcohol Use and Opioid Use Disorder.
Alcohol is the most widely used addictive substance. Severe alcohol abuse is diagnosed as "alcohol use disorder" (AUD). A common and harmful drinking pattern is binge drinking that elevates a person's blood alcohol concentration to ≥ 0.08%. Such drinking may be an early indicator of AUD. Opioid misuse and dependence have become worldwide crises. Patterned consumption of various opioids can develop into opioid use disorder (OUD). An intertwined epidemic exists between opioid abuse, alcohol addiction, and binge drinking. Currently, studies on the interaction of AUD and OUD are limited and the underlying mechanisms linking these disorders remains unclear. We reviewed studies on AUD and OUD and utilized Ingenuity Pathway Analysis (IPA) to identify mechanisms of AUD and OUD interaction and potential gene targets for therapeutic agents. According to IPA Canonical Pathways Analysis, Gamma-aminobutyric Acid (GABA) Receptor Signaling, Neuroinflammation Signaling Pathway, Opioid Signaling Pathway and Dopamine-DARPP32 Feedback in cAMP Signaling are potential contributors to the interaction of AUD and OUD.
期刊介绍:
The Journal of Drug and Alcohol Research (JDAR) is a scholarly open access, peer-reviewed, and fully refereed journal dedicated to publishing sound papers on advances in the field of drug, opiate, nicotine and alcohol abuse, both basic and clinical. The journal will consider papers from all sub-disciplines and aspects of drug abuse, dependence and addiction research. Manuscripts will be published online as soon as they are accepted, which will reduce the time of publication. Because there are no space limitations or favored topics, all papers, within the scope of the journal, judged to be sound by the reviewers, will be published.