血管紧张素转换酶插入/缺失多态性与儿童哮喘易感性:一项荟萃分析

IF 2.1 4区医学 Q3 PERIPHERAL VASCULAR DISEASE Journal of the Renin-Angiotensin-Aldosterone System Pub Date : 2020-04-01 DOI:10.1177/1470320320923475

Zhengyang Shao, Haili Jin, Hong Sun, Chenxia Dong, Binbin Xu, Lu Zhan

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引用次数: 3

摘要

目的:本荟萃分析评估血管紧张素转换酶(ACE)插入/缺失(I/D)多态性与儿童哮喘风险的相关性。方法:系统检索PubMed、Web of Science、Embase和CNKI数据库相关文献，应用比值比(OR)和95%置信区间(CI)确定相关性强弱。结果:7篇文章802例，对照632例符合纳入标准。因此，ACE I/D多态性与儿童哮喘风险升高有关(D / I: OR = 1.87, 95% CI = 1.59-2.20;优势模型:OR =1.53, 95% CI = 1.28-1.81;隐性模型:OR =1.54, 95% CI = 1.28 ~ 1.85;DD vs II: OR =2.95, 95% CI = 2.19-3.98;DI vs II: OR = 0.96, 95% CI = 0.78-1.19)。按种族分层的亚组分析显示亚洲人有显著的相关性。结论:本荟萃分析表明，ACE I/D多态性可能与儿童哮喘的风险有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to pediatric asthma: A meta-analysis.

Objective: The correlation of the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism with pediatric asthma risk was assessed in this meta-analysis.

Methods: PubMed, Web of Science, Embase and CNKI databases were systematically searched for relevant literature, followed by application of odds ratios (OR) along with 95% confidence interval (CI) for determining the strength of relationship.

Results: Seven articles with 802 cases and 632 controls fulfilled the inclusion criteria. As a result, the ACE I/D polymorphism was related to elevated pediatric asthma risk (D vs I: OR = 1.87, 95% CI = 1.59-2.20; dominant model: OR =1.53, 95% CI = 1.28-1.81; recessive model: OR =1.54, 95% CI = 1.28-1.85; DD vs II: OR =2.95, 95% CI = 2.19-3.98; DI vs II: OR = 0.96, 95% CI = 0.78-1.19). Subgroup analysis stratified by race revealed significant interrelation in Asians.

Conclusion: This meta-analysis demonstrated that the ACE I/D polymorphism might be related to the risk of pediatric asthma.

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来源期刊

Journal of the Renin-Angiotensin-Aldosterone System 医学-外周血管病

CiteScore

6.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： JRAAS is a peer-reviewed, open access journal, serving as a resource for biomedical professionals, primarily with an active interest in the renin-angiotensin-aldosterone system in humans and other mammals. It publishes original research and reviews on the normal and abnormal function of this system and its pharmacology and therapeutics, mostly in a cardiovascular context but including research in all areas where this system is present, including the brain, lungs and gastro-intestinal tract.