评价siRNA对人神经元性畸胎癌NT2细胞系SOX2OT表达的影响。

Q3 Medicine Human Antibodies Pub Date : 2020-01-01 DOI:10.3233/HAB-200418

Zahra Sadeghi, Fateme Dodange, Parichehr Maleki, Mohadeseh Zarei, Mohammad Taheri, Jamshid Raheb

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引用次数: 0

摘要

近年来，非编码RNA长链(lncRNAs)作为调控干细胞多能性(pluripotent)基因表达的分子受到了广泛的关注。最近，我们的同事研究了其中一种被称为SOX2OT的rna在食管鳞状细胞癌中的作用，并发现其表达与一些细胞增殖调节基因同时增加。在本研究中，我们利用SOX2OT基因设计合适的引物，研究了siRNA对SOX2OT表达的影响。

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Evaluating the effect of siRNA on SOX2OT expression in the human neuron-committed teratocarcinoma NT2 cell line.

Non-coding RNA elongated (lncRNAs) have recently attracted as molecules that regulate gene expression of the pluripotent properties (pluripotency) of stem cells. Recently our colleagues examined the role of one of these RNAs called SOX2OT in esophageal squamous cell carcinoma, and found a concomitant increase in its expression with some regulatory genes of cell proliferation. In the present study, using the design of suitable primers from SOX2OT gene, we investigated the effect of siRNA on expression of SOX2OT.

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来源期刊

Human Antibodies Medicine-Immunology and Allergy

CiteScore

3.50

自引率

0.00%

发文量

期刊介绍： Human Antibodies is an international journal designed to bring together all aspects of human hybridomas and antibody technology under a single, cohesive theme. This includes fundamental research, applied science and clinical applications. Emphasis in the published articles is on antisera, monoclonal antibodies, fusion partners, EBV transformation, transfections, in vitro immunization, defined antigens, tissue reactivity, scale-up production, chimeric antibodies, autoimmunity, natural antibodies/immune response, anti-idiotypes, and hybridomas secreting interesting growth factors. Immunoregulatory molecules, including T cell hybridomas, will also be featured.