PRMT5在癌症中的功能和靶向性。

IF 4.1 Q2 CELL BIOLOGY Cell Stress Pub Date : 2020-07-13 DOI:10.15698/cst2020.08.228

Hyungsoo Kim, Ze'ev A Ronai

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引用次数: 85

摘要

蛋白质甲基转移酶在癌症发生、进展和治疗反应的许多调控途径中发挥关键作用。在这里，我们讨论了PRMT5的功能，PRMT5是PRMT家族的9个成员之一，在控制肿瘤内部和外部微环境信号通路中的致癌过程。我们讨论了PRMT5对组蛋白甲基化和调控蛋白甲基化的影响，包括那些参与RNA剪接、细胞周期、细胞死亡和代谢信号传导的蛋白。总之，我们强调了PRMT5在癌症中的调节和功能的重要性，这为针对PRMT5的治疗方式提供了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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PRMT5 function and targeting in cancer.

Protein methyl transferases play critical roles in numerous regulatory pathways that underlie cancer development, progression and therapy-response. Here we discuss the function of PRMT5, a member of the nine-member PRMT family, in controlling oncogenic processes including tumor intrinsic, as well as extrinsic microenvironmental signaling pathways. We discuss PRMT5 effect on histone methylation and methylation of regulatory proteins including those involved in RNA splicing, cell cycle, cell death and metabolic signaling. In all, we highlight the importance of PRMT5 regulation and function in cancer, which provide the foundation for therapeutic modalities targeting PRMT5.

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来源期刊

Cell Stress Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (miscellaneous)

CiteScore

13.50

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： Cell Stress is an open-access, peer-reviewed journal that is dedicated to publishing highly relevant research in the field of cellular pathology. The journal focuses on advancing our understanding of the molecular, mechanistic, phenotypic, and other critical aspects that underpin cellular dysfunction and disease. It specifically aims to foster cell biology research that is applicable to a range of significant human diseases, including neurodegenerative disorders, myopathies, mitochondriopathies, infectious diseases, cancer, and pathological aging. The scope of Cell Stress is broad, welcoming submissions that represent a spectrum of research from fundamental to translational and clinical studies. The journal is a valuable resource for scientists, educators, and policymakers worldwide, as well as for any individual with an interest in cellular pathology. It serves as a platform for the dissemination of research findings that are instrumental in the investigation, classification, diagnosis, and therapeutic management of major diseases. By being open-access, Cell Stress ensures that its content is freely available to a global audience, thereby promoting international scientific collaboration and accelerating the exchange of knowledge within the research community.