α -8整合素链(itga8)在肾脏肾小球稳态中的作用。

IF 2.4 Q1 PEDIATRICS Molecular and cellular pediatrics Pub Date : 2020-10-01 DOI:10.1186/s40348-020-00105-5
Ines Marek, Karl Friedrich Hilgers, Wolfgang Rascher, Joachim Woelfle, Andrea Hartner
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引用次数: 8

摘要

肾小球肾炎导致肾小球细胞的失调,并可能以慢性改变和随后的肾功能丧失而告终。因此,了解维持肾小球完整性的机制是治疗干预的关键先决条件。α -8整合素链似乎通过赋予肾毛细血管丛的机械稳定性和功能支持,在维持肾小球稳态中起着重要作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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A role for the alpha-8 integrin chain (itga8) in glomerular homeostasis of the kidney.

Glomerulonephritis results in a dysregulation of glomerular cells and may end up in chronic alterations and subsequent loss of renal function. Therefore, understanding mechanisms, which contribute to maintain glomerular integrity, is a pivotal prerequisite for therapeutic interventions. The alpha-8 integrin chain seems to be an important player to maintain glomerular homeostasis by conferring mechanical stability and functional support for the renal capillary tuft.

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