COVID-19 中的羟氯喹:研究表明过早决定疗效的同时也敲响了安全性的警钟。

IF 3.1 Q2 PHARMACOLOGY & PHARMACY Clinical Pharmacology : Advances and Applications Pub Date : 2020-08-17 eCollection Date: 2020-01-01 DOI:10.2147/CPAA.S269156
Sitaram Khadka, Dhan Bahadur Shrestha, Pravash Budhathoki, Era Rawal
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引用次数: 0

摘要

冠状病毒病(COVID-19)大流行已成为全球疾病负担。在武汉首次爆发后的七个月内,全球已有超过 1 600 万人受到影响。目前正在采用不同的治疗方法、治疗剂和预防剂进行治疗。在成熟的疗法问世之前,药物的再利用是更好的出路。羟氯喹(HCQ)是治疗 COVID-19 的潜在药物。据报道,羟氯喹会引发不同程度的心脏不良事件,因此安全性问题成为首要目标。即使是在这样一个全球性的健康危机中,要解决合理的药物治疗问题,也必须进行风险效益分析。在本文中,我们希望评估 HCQ 在治疗 COVID-19 中的安全性和有效性。
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Hydroxychloroquine in COVID-19: The Study Points to Premature Decisions on Efficacy While Bells Ringing for Safety.

Coronavirus disease (COVID-19) pandemic has been a global disease burden. It has affected more than sixteen million people in the world within seven months of its first outbreak in Wuhan. Different treatment modalities, therapeutic and prophylactic agents for its therapy are underway. Until the proven therapy gets available, repurposing of drugs is a better way out. Hydroxychloroquine (HCQ) has been a potential recourse of treatment in this regard for COVID-19 management. As different episodes of cardiac adverse events of HCQ are reported, safety concerns are now a prime objective. The risk-benefit analysis is mandatory to address rational drug therapy even in such a global health crisis. In this article, we want to evaluate the safety and efficacy of HCQ in COVID-19 management.

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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
14
审稿时长
16 weeks
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