miR-210在生物系统中的作用:最新综述

IF 1.1 4区 生物学 Q4 GENETICS & HEREDITY Human Heredity Pub Date : 2019-01-01 Epub Date: 2020-09-09 DOI:10.1159/000509280
Xu Hui, Hisham Al-Ward, Fahmi Shaher, Chun-Yang Liu, Ning Liu
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引用次数: 8

摘要

背景:MicroRNAs (miRNAs)是一组长度为19-23个核苷酸的非编码rna,被认为是真核细胞中调节基因表达的强大分子。mirna通过直接或间接的机制刺激基因表达的转录后调控。总结:miR-210在缺氧条件下的细胞中高度上调,从而揭示了其对细胞耐力的重要意义。诱导这种mRNA的表达是细胞低氧反应的重要特征,也是HIF最一致和最有力的目标。关键信息:miR-210在HIF-1α的作用下参与细胞周期、DNA修复、免疫与炎症、血管生成、代谢、巨噬细胞调控等多种细胞功能。它在t细胞分化和刺激中也起着重要的调节作用。
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The Role of miR-210 in the Biological System: A Current Overview.

Background: MicroRNAs (miRNAs) represent a group of non-coding RNAs measuring 19-23 nucleotides in length and are recognized as powerful molecules that regulate gene expression in eukaryotic cells. miRNAs stimulate the post-transcriptional regulation of gene expression via direct or indirect mechanisms.

Summary: miR-210 is highly upregulated in cells under hypoxia, thereby revealing its significance to cell endurance. Induction of this mRNA expression is an important feature of the cellular low-oxygen response and the most consistent and vigorous target of HIF. Key Message: miR-210 is involved in many cellular functions under the effect of HIF-1α, including the cell cycle, DNA repair, immunity and inflammation, angiogenesis, metabolism, and macrophage regulation. It also plays an important regulatory role in T-cell differentiation and stimulation.

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来源期刊
Human Heredity
Human Heredity 生物-遗传学
CiteScore
2.50
自引率
0.00%
发文量
12
审稿时长
>12 weeks
期刊介绍: Gathering original research reports and short communications from all over the world, ''Human Heredity'' is devoted to methodological and applied research on the genetics of human populations, association and linkage analysis, genetic mechanisms of disease, and new methods for statistical genetics, for example, analysis of rare variants and results from next generation sequencing. The value of this information to many branches of medicine is shown by the number of citations the journal receives in fields ranging from immunology and hematology to epidemiology and public health planning, and the fact that at least 50% of all ''Human Heredity'' papers are still cited more than 8 years after publication (according to ISI Journal Citation Reports). Special issues on methodological topics (such as ‘Consanguinity and Genomics’ in 2014; ‘Analyzing Rare Variants in Complex Diseases’ in 2012) or reviews of advances in particular fields (‘Genetic Diversity in European Populations: Evolutionary Evidence and Medical Implications’ in 2014; ‘Genes and the Environment in Obesity’ in 2013) are published every year. Renowned experts in the field are invited to contribute to these special issues.
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