不同形态乳腺微浸润癌121例临床病理特征分析。

IF 1.8 Q3 ONCOLOGY Breast Cancer : Basic and Clinical Research Pub Date : 2020-10-05 eCollection Date: 2020-01-01 DOI:10.1177/1178223420948482
ChangYin Feng, QiaoLing Zheng, YingHong Yang
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引用次数: 1

摘要

目的:探讨乳腺微侵性癌(MI)的临床病理特征。方法:回顾性分析121例乳腺心肌梗死的临床资料。采用苏木精和伊红染色(H&E)对全部肿瘤进行病理评价。分析肿瘤大小、组织学分级、肿瘤浸润淋巴细胞(til)、MI数量、MI类型与淋巴结转移的关系。结果:高级别导管原位癌(DCIS)发生率为86%,多发性原位癌发生率为63.6%。肿瘤体积越大,DCIS分级越高,MIs数量越多;3.3%的DCIS有丰富的til(淋巴细胞/间质> 30%),26.5%的MIs有丰富的til。MIs的A型以单细胞和小簇实体细胞为特征。MIs的B型肿瘤细胞可形成腺管。微创的正式分级是具有挑战性的/不可能的,因为其有限的尺寸排除了代表性的有丝分裂计数。但可以报道核级和小管(分化)级。72.7%的病例为A型MIs, 27.3%的病例为B型MIs。B型高伴中度DCIS。只有6.6%的心肌梗死患者有淋巴结转移,这主要与心肌梗死中TILs较少有关。结论:高级别DCIS易发生乳腺MI,肿瘤大小大于3.5 cm可出现多发浸润灶。浸润性肿瘤伴较差的TILs可能是DCIS-Mi患者发生淋巴结转移的危险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Breast Microinvasive Carcinoma With Different Morphologies: Analysis of Clinicopathologic Features of 121 Cases.

Purpose: To investigate the clinicopathological features of patients with breast microinvasive carcinoma (MI).

Methods: The clinical data of 121 cases with breast MI were retrospectively collected. The whole tumor in each case was stained with hematoxylin and eosin (H&E) for pathological evaluation. The relationships among size of tumor, histological grade, tumor-infiltrating lymphocytes (TILs), the number of MIs, type of MI, and lymph node metastasis were analyzed.

Results: It was revealed that 86% of the cases had high-grade ductal carcinoma in situ (DCIS) and 63.6% had multiple MIs. The larger size of the tumors, the higher the grade of DCIS, the more the number of MIs; 3.3% of cases had rich TILs (lymphocyte/stroma > 30%) in the DCIS, and 26.5% had rich TILs in MIs. The type A of MIs is characterized by single cells and small clusters of solid cells. Tumor cells in type B of MIs can form glandular ducts. Formal grading of microinvasive is challenging/impossible due to its limited size precluding a representative mitotic count. But nuclear grade and tubule (differentiation) grades can be reported. In addition, 72.7% of cases had type A of MIs and 27.3% of cases had type B of MIs. Type B was found to be highly accompanied by moderate-grade DCIS. Only 6.6% of patients with MI had lymph node metastasis, which was mainly related to MIs with less TILs.

Conclusion: Breast MI is easy to occur in high-grade DCIS, and multiple infiltration foci may be observed in case with tumor size of higher than 3.5 cm. Microinvasive carcinoma with poor TILs maybe a risk factor for lymph node metastasis in patient with DCIS-Mi.

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来源期刊
CiteScore
5.10
自引率
3.40%
发文量
22
审稿时长
8 weeks
期刊介绍: Breast Cancer: Basic and Clinical Research is an international, open access, peer-reviewed, journal which considers manuscripts on all areas of breast cancer research and treatment. We welcome original research, short notes, case studies and review articles related to breast cancer-related research. Specific areas of interest include, but are not limited to, breast cancer sub types, pathobiology, metastasis, genetics and epigenetics, mammary gland biology, breast cancer models, prevention, detection, therapy and clinical interventions, and epidemiology and population genetics.
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