对“代谢重编程相关基因预测直肠癌总生存率”的评论。

IF 5.3 2区医学 Q1 Biochemistry, Genetics and Molecular Biology Journal of Cellular and Molecular Medicine Pub Date : 2020-11-01 Epub Date: 2020-10-22 DOI:10.1111/jcmm.15938

Ruihuan Shen

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引用次数: 2

摘要

目前这篇论文是对代谢重编程相关基因预测直肠癌总生存率的一篇评论(jianqing Lin et al 2020)。作者得出结论:“在TCGA数据库中，高风险患者的生存结果明显低于低风险患者。”此外，在GEO数据库中，高风险患者的生存结果仍明显低于低风险患者。但在他们发表的论文《直肠癌预后代谢基因的生存分析》中，图3显示，在假设检验过程中，他们的研究显然存在I型错误。

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Commentary on 'Metabolic reprogramming-associated genes predict overall survival for rectal cancer'.

The current paper is a commentary on the Metabolic reprogramming-associated genes predict overall survival for rectal cancer (Jian-Qing Lin et al 2020). The authors concluded that 'Patients with high-risk demonstrated significantly poorer survival outcomes than patients with low-risk in the TCGA database. Also, patients with high-risk still showed significantly poorer survival outcomes than patients with low-risk in the GEO database'. But the figure 3 in their published paper, 'Survival analyses for the prognostic metabolic genes in rectal cancer', presented that there was type I error in their study during the hypothesis testing process, obviously.

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来源期刊

Journal of Cellular and Molecular Medicine 医学-细胞生物学

CiteScore

10.00

自引率

1.90%

发文量

496

审稿时长

28 weeks

期刊介绍： Bridging physiology and cellular medicine, and molecular biology and molecular therapeutics, Journal of Cellular and Molecular Medicine publishes basic research that furthers our understanding of the cellular and molecular mechanisms of disease and translational studies that convert this knowledge into therapeutic approaches.