CYP24A1 rs1570669变异对泌尿系统肿瘤具有保护作用

IF 1.3 4区医学 Q4 GENETICS & HEREDITY Public Health Genomics Pub Date : 2020-01-01 Epub Date: 2020-10-28 DOI:10.1159/000509190

Yao Sun, Xiang Wang, Jiamin Wu, Zichao Xiong, Haiyue Li, Yuanwei Liu, Jianfeng Liu, Yipeng Ding, Tianbo Jin

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引用次数: 0

摘要

背景:泌尿系统常见的恶性肿瘤包括肾细胞癌、膀胱癌和前列腺癌。CYP24A1基因与前列腺癌关系的研究主要集中在欧美人群，在中国人群中的研究较少。因此，我们选择膀胱癌、前列腺癌和肾癌作为研究对象，探讨CYP24A1对泌尿系统肿瘤遗传易感性的影响。材料与方法:通过Agena MassARRAY对529例患者和523例对照的rs6068816、rs2296241、rs2762934和rs1570669进行基因分型。采用Logistic回归分析评价两个snp与泌尿系统癌易感性的奇比(or)和95%置信区间(CIs)。数据库预测CYP24A1基因在泌尿系统癌中的表达。结果:具有CYP24A1 rs1570669 AG基因型的个体发生泌尿系统肿瘤的风险降低28% (OR = 0.72, 95% CI: 0.56-1.13, p = 0.016)，发生肾癌的风险降低31% (OR = 0.69, 95% CI: 0.51-0.92, p = 0.012)。结论:CYP24A1 rs1570669可能在泌尿系统肿瘤和肾癌的易感性中起重要作用。

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CYP24A1 rs1570669 Variant Has a Protective Effect against Tumors of the Urinary System.

Background: Common malignant tumors of the urinary system include renal cell carcinoma, bladder carcinoma, and prostate cancer. The research on the CYP24A1 gene for prostate cancer is mainly concentrated in European and American populations, and there are few studies in the Chinese population. Therefore, we selected bladder cancer, prostate cancer, and renal cancer as the research objects to explore the influence of CYP24A1 on the genetic susceptibility of urinary system tumors.

Materials and methods: rs6068816, rs2296241, rs2762934, and rs1570669 in 529 patients and 523 controls were genotyped via the Agena MassARRAY. Logistic regression analysis was used to evaluate the odd ratios (ORs) and 95% confidence intervals (CIs) of two SNPs with susceptibility of urinary system cancer. Database predicts the expression of the CYP24A1 gene in urinary system cancer.

Results: Individuals with the AG genotype of CYP24A1 rs1570669 has a 28% lower risk of developing urinary system tumors (OR = 0.72, 95% CI: 0.56-1.13, p = 0.016) and has a 31% lower risk of developing renal cancer (OR = 0.69, 95% CI: 0.51-0.92, p = 0.012).

Conclusions: CYP24A1 rs1570669 may play an important role in the susceptibility of tumors of the urinary system and renal cancer.

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来源期刊

Public Health Genomics 医学-公共卫生、环境卫生与职业卫生

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： ''Public Health Genomics'' is the leading international journal focusing on the timely translation of genome-based knowledge and technologies into public health, health policies, and healthcare as a whole. This peer-reviewed journal is a bimonthly forum featuring original papers, reviews, short communications, and policy statements. It is supplemented by topic-specific issues providing a comprehensive, holistic and ''all-inclusive'' picture of the chosen subject. Multidisciplinary in scope, it combines theoretical and empirical work from a range of disciplines, notably public health, molecular and medical sciences, the humanities and social sciences. In so doing, it also takes into account rapid scientific advances from fields such as systems biology, microbiomics, epigenomics or information and communication technologies as well as the hight potential of ''big data'' for public health.