利用实验性子宫内膜异位症小鼠模型解读mirna在子宫内膜异位症病理生理中的作用。

4区生物学 Q3 Medicine Advances in Anatomy Embryology and Cell Biology Pub Date : 2020-01-01 DOI:10.1007/978-3-030-51856-1_5

Ayushi Vashisht, Zahraa Alali, Warren B Nothnick

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引用次数: 1

摘要

子宫内膜异位症是一种神秘的疾病，我们对这种疾病的发展方式和原因仍然知之甚少。近年来，miRNAs，一种通过转录后调控基因表达的小非编码rna，在子宫内膜异位症病理生理中的作用已被评估。本文就mirna在子宫内膜异位症相关的子宫内膜生理和病理生理中的作用作一综述。然后，我们将讨论子宫内膜异位症研究中使用的小鼠模型，以及在研究mirna在子宫内膜异位症病理生理中的作用时将其中一些模型纳入研究。最后，我们对小鼠模型在剖析mirna在子宫内膜异位症病理生理中的作用提供了未来的展望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Deciphering the Role of miRNAs in Endometriosis Pathophysiology Using Experimental Endometriosis Mouse Models.

Endometriosis is an enigmatic disease for which we still have a poor understanding on how and why the disease develops. In recent years, miRNAs, small noncoding RNAs which regulate gene expression posttranscriptionally, have been evaluated for their role in endometriosis pathophysiology. This review will provide a brief summary on the role of miRNAs in endometrial physiology and pathophysiology as related to endometriosis. We will then discuss mouse models used in endometriosis research and the incorporation of some of these models in studies which examined the role of miRNAs in endometriosis pathophysiology. We conclude with providing future prospective on the role of mouse models in dissecting the role of miRNAs in endometriosis pathophysiology.

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来源期刊

Advances in Anatomy Embryology and Cell Biology 生物-发育生物学

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2.00

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0.00%

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期刊介绍： "Advances in Anatomy, Embryology and Cell Biology" presents critical reviews on all topical fields of normal and experimental anatomy including cell biology. The multi-perspective presentation of morphological aspects of basic biological phenomen in the human constitutes the main focus of the series. The contributions re-evaluate the latest findings and show ways for further research.

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