{"title":"经皮肤测试和嗜碱性粒细胞活化测试证实的硫代胆碱苷即刻过敏反应：病例报告和文献综述。","authors":"Nucera Eleonora, Inchingolo Riccardo, Ferraironi Manuela, Aruanno Arianna, Chini Raffaella, Rizzi Angela","doi":"10.12932/AP-250320-0793","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Thiocolchicoside is a muscle relaxant, anti-inflammatory, and analgesic. Administered orally, intramuscularly, or topically, this drug is used in the symptomatic treatment of muscular spasms and rheumatologic disorders. Despite its extensive use, thiocolchicoside is a very rare sensitizer.</p><p><strong>Objective: </strong>To evaluate IgE-mediated reaction to thiocolchicoside by basophil activation test.</p><p><strong>Methods: </strong>Allergological work-up with skin prick tests, intradermal tests and basophil activation test with thiocolchicoside.</p><p><strong>Results: </strong>We report the first case of immediate reaction to thiocolchicoside confirmed by basophil activation test in addition to positive skin tests.</p><p><strong>Conclusions: </strong>BAT can be considered a complementary diagnostic tool to demonstrate an IgE-mediated reaction also for muscle relaxant drugs.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Immediate allergic reaction to thiocolchicoside confirmed by skin testing and basophil activation test: A case report and literature review.\",\"authors\":\"Nucera Eleonora, Inchingolo Riccardo, Ferraironi Manuela, Aruanno Arianna, Chini Raffaella, Rizzi Angela\",\"doi\":\"10.12932/AP-250320-0793\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Thiocolchicoside is a muscle relaxant, anti-inflammatory, and analgesic. Administered orally, intramuscularly, or topically, this drug is used in the symptomatic treatment of muscular spasms and rheumatologic disorders. Despite its extensive use, thiocolchicoside is a very rare sensitizer.</p><p><strong>Objective: </strong>To evaluate IgE-mediated reaction to thiocolchicoside by basophil activation test.</p><p><strong>Methods: </strong>Allergological work-up with skin prick tests, intradermal tests and basophil activation test with thiocolchicoside.</p><p><strong>Results: </strong>We report the first case of immediate reaction to thiocolchicoside confirmed by basophil activation test in addition to positive skin tests.</p><p><strong>Conclusions: </strong>BAT can be considered a complementary diagnostic tool to demonstrate an IgE-mediated reaction also for muscle relaxant drugs.</p>\",\"PeriodicalId\":2,\"journal\":{\"name\":\"ACS Applied Bio Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2024-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Bio Materials\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.12932/AP-250320-0793\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.12932/AP-250320-0793","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
Immediate allergic reaction to thiocolchicoside confirmed by skin testing and basophil activation test: A case report and literature review.
Background: Thiocolchicoside is a muscle relaxant, anti-inflammatory, and analgesic. Administered orally, intramuscularly, or topically, this drug is used in the symptomatic treatment of muscular spasms and rheumatologic disorders. Despite its extensive use, thiocolchicoside is a very rare sensitizer.
Objective: To evaluate IgE-mediated reaction to thiocolchicoside by basophil activation test.
Methods: Allergological work-up with skin prick tests, intradermal tests and basophil activation test with thiocolchicoside.
Results: We report the first case of immediate reaction to thiocolchicoside confirmed by basophil activation test in addition to positive skin tests.
Conclusions: BAT can be considered a complementary diagnostic tool to demonstrate an IgE-mediated reaction also for muscle relaxant drugs.
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