青光眼是大脑中的神经变性。

IF 3.1 Q1 OPHTHALMOLOGY Eye and Brain Pub Date : 2021-01-18 eCollection Date: 2021-01-01 DOI:10.2147/EB.S293765
Jane W Chan, Noel C Y Chan, Alfredo A Sadun
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引用次数: 25

摘要

青光眼是一组以视神经进行性变性导致不可逆失明为特征的疾病,可以被认为是眼睛和大脑的神经退行性疾病。来自人类和动物研究的越来越多的证据表明,青光眼与阿尔茨海默病(AD)和其他tau病(如慢性创伤性脑病(CTE)和额颞叶痴呆)有一些共同的神经退行性途径。该假说是基于tau蛋白的黏附途径假说和扩散假说。载脂蛋白E (APOE)基因不仅与AD有关,还与原发性开角型青光眼(POAG)有关。本综述将重点介绍近20年来PubMed中显示POAG与AD致病重叠的相关文献。阿尔茨海默病和其他牛头病中导致经突触神经变性的神经退行性通路也可能与青光眼神经变性相似。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Glaucoma as Neurodegeneration in the Brain.

Glaucoma, a group of diseases characterized by progressive optic nerve degeneration that results in irreversible blindness, can be considered a neurodegenerative disorder of both the eye and the brain. Increasing evidence from human and animal studies have shown that glaucoma shares some common neurodegenerative pathways with Alzheimer's disease (AD) and other tauopathies, such as chronic traumatic encephalopathy (CTE) and frontotemporal dementia. This hypothesis is based on the focal adhesion pathway hypothesis and the spreading hypothesis of tau. Not only has the Apolipoprotein E (APOE) gene been shown to be associated with AD, but also with primary open angle glaucoma (POAG). This review will highlight the relevant literature in the past 20 years from PubMed that show the pathogenic overlap between POAG and AD. Neurodegenerative pathways that contribute to transsynaptic neurodegeneration in AD and other tauopathies might also be similar to those in glaucomatous neurodegeneration.

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来源期刊
Eye and Brain
Eye and Brain OPHTHALMOLOGY-
CiteScore
7.90
自引率
2.30%
发文量
12
审稿时长
16 weeks
期刊介绍: Eye and Brain is an international, peer-reviewed, open access journal focusing on basic research, clinical findings, and expert reviews in the field of visual science and neuro-ophthalmology. The journal’s unique focus is the link between two well-known visual centres, the eye and the brain, with an emphasis on the importance of such connections. All aspects of clinical and especially basic research on the visual system are addressed within the journal as well as significant future directions in vision research and therapeutic measures. This unique journal focuses on neurological aspects of vision – both physiological and pathological. The scope of the journal spans from the cornea to the associational visual cortex and all the visual centers in between. Topics range from basic biological mechanisms to therapeutic treatment, from simple organisms to humans, and utilizing techniques from molecular biology to behavior. The journal especially welcomes primary research articles or review papers that make the connection between the eye and the brain. Specific areas covered in the journal include: Physiology and pathophysiology of visual centers, Eye movement disorders and strabismus, Cellular, biochemical, and molecular features of the visual system, Structural and functional organization of the eye and of the visual cortex, Metabolic demands of the visual system, Diseases and disorders with neuro-ophthalmic manifestations, Clinical and experimental neuro-ophthalmology and visual system pathologies, Epidemiological studies.
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