Prasanta Kumar Sarkar, Chitrangada Das Mukhopadhyay
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Ayurvedic metal nanoparticles could be novel antiviral agents against SARS-CoV-2.
Purpose of review: The pandemic COVID-19 has affected more than seventy million people globally. The whole world is eagerly waiting for an effective antiviral therapy to combat COVID-19, but it is yet to get. The emergence of COVID-19 makes imperative the need for safe and potent antiviral drugs. Many metal nanoparticles exhibit significant antiviral potential against many viral diseases. The Ayurvedic system of medicine is the treasure of many metal nanoparticulate drugs termed as Bhasma.
Recent findings: Gold, silver, copper, zinc and iron oxide nanoparticles are effective against coronavirus. A possible mechanism of action of the metal nanoparticles against coronavirus is a disruption of outer layers of coronavirus. Swarna Bhasma, Rajata Bhasma, Tamra Bhasma and Yashada Bhasma are recommended for COVID-19 treatment due to the ability to reduce the plasma interleukins, interferons and TNFα levels.
Summary: The Ayurvedic Bhasma preparations are unique metal nanoparticles. These metal nanoparticles are safe, stable in solid state and are having excellent biological activities. Ayurvedic metal nanoparticles, Swarna Bhasma, Rajata Bhasma, Tamra Bhasma and Yashada Bhasma could be proved as novel antiviral agents against SARS-CoV-2 for their anti-inflammatory, immunomodulatory, antiviral and adjuvant activities.
期刊介绍：
The overall aim of the International Nano Letters is to bring science and applications together on nanoscale and nanostructured materials with emphasis on synthesis, processing, characterization, and applications of materials containing true nanosize dimensions or nanostructures that enable novel/enhanced properties or functions. It is directed at both academic researchers and practicing engineers. International Nano Letters is covering fundamental and applied research in all disciplines of science, engineering and medicine. INL publishes all aspects of nanoscale science and technology dealing with materials synthesis, processing, nanofabrication, nano-polymer, nano-catalyst, nano-particles, nano-probes, spectroscopy, properties, biological systems, nano-structures, theory and computation, nano-electronics, nano-optics, nano-mechanics, nano-devices, nano-detection, nano-biotechnology, nano-medicine, nano-drug delivery, nano-toxicology. All articles should emphasize original results relating to experimental, theoretical, computational, and/or applications of nanomaterials. All contributions will be peer reviewed.
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