中重度新冠肺炎住院患者氧化应激指标的评价

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL Romanian Journal of Internal Medicine Pub Date : 2021-11-20 Print Date: 2021-12-01 DOI:10.2478/rjim-2021-0014
Dragica Zendelovska, Emilija Atanasovska, Marija Petrushevska, Katerina Spasovska, Milena Stevanovikj, Ilir Demiri, Nikola Labachevski
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引用次数: 14

摘要

背景。临床证据表明,COVID-19患者的氧化应激增加,这种氧化还原状态的恶化可能导致疾病的进展。目标。为了研究氧化应激,我们测量了氧化应激参数,即PAT(总抗氧化能力,铁还原)和d- rom(血浆过氧化物)。此外,我们还研究了它们与三级医院住院的中重度COVID-19患者血清中最常用的临床参数CRP、LDH和NLR的相关性。方法。采用分析光度法测定50例住院患者血清中PAT和d- rom含量。每组分别采集两份样本,相隔7天后立即进行分析。结果。所有患者入院时血浆过氧化物值都更高,氧化应激参数与CRP、LDH和NLR之间存在显著相关性。(pConclusion。我们认为,在COVID-19疾病开始时使用OSI为氧化应激的一般评估提供了一个有价值的起点,从而能够根据疾病严重程度更好地对患者进行分类。
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Evaluation of oxidative stress markers in hospitalized patients with moderate and severe COVID-19.

Background. Clinical evidence suggests increased oxidative stress in COVID-19 patients and this worsened redox status could potentially contribute to the progression of the disease. Objectives. To investigate the oxidative stress we have measured oxidative stress parameters, namely, PAT (total antioxidant power, iron reducing) and d-ROMs (plasma peroxides). Additionally we have investigated their correlation with the most frequently used clinical parameters CRP, LDH, and NLR in serum from moderate and severe COVID-19 patients hospitalized in a tertiary hospital. Methods. PAT and d-ROMs were determined by analytical photometric metric method in serum from 50 hospitalized patients. For each of them, two samples were collected and analyzed immediately after collection seven days apart. Results. All patients at admission had a much higher value for plasma peroxides and a significant correlation between oxidative stress parameters and CRP, LDH, and NLR. (p<0.05), except for OS index (OSI) vs CRP in the severe group. At discharge, plasma peroxides were reduced and OSI was improved in the moderate group. Conclusion. We consider that using OSI at the beginning of COVID-19 disease presents a valuable starting point for the general assessment of oxidative stress and hence enabling a better triage of the patients in terms of disease severity.

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来源期刊
Romanian Journal of Internal Medicine
Romanian Journal of Internal Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
5.30%
发文量
35
审稿时长
15 weeks
期刊介绍: Romanian Journal of Physics is a journal publishing physics contributions on the following themes: •Theoretical Physics & Applied Mathematics •Nuclear Physics •Solid State Physics & Materials Science •Statistical Physics & Quantum Mechanics •Optics •Spectroscopy •Plasma & Lasers •Nuclear & Elementary Particles Physics •Atomic and Molecular Physics •Astrophysics •Atmosphere and Earth Science •Environment Protection
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