内在无序蛋白领域的新进展:从生理和病理的液-液相变看细胞生物学中基于内在无序的出现

IF 10.4 1区生物学 Q1 BIOPHYSICS Annual Review of Biophysics Pub Date : 2021-05-06 Epub Date: 2021-01-27 DOI:10.1146/annurev-biophys-062920-063704

Vladimir N Uversky

{"title":"内在无序蛋白领域的新进展:从生理和病理的液-液相变看细胞生物学中基于内在无序的出现","authors":"Vladimir N Uversky","doi":"10.1146/annurev-biophys-062920-063704","DOIUrl":null,"url":null,"abstract":"This review deals with two important concepts-protein intrinsic disorder and proteinaceous membrane-less organelles (PMLOs). The past 20 years have seen an upsurge of scientific interest in these phenomena. However, neither are new discoveries made in this century, but instead are timely reincarnations of old ideas that were mostly ignored by the scientific community for a long time. Merging these concepts in the form of the intrinsic disorder-based biological liquid-liquid phase separation provides a basis for understanding the molecular mechanisms of PMLO biogenesis.","PeriodicalId":50756,"journal":{"name":"Annual Review of Biophysics","volume":"50 ","pages":"135-156"},"PeriodicalIF":10.4000,"publicationDate":"2021-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"41","resultStr":"{\"title\":\"Recent Developments in the Field of Intrinsically Disordered Proteins: Intrinsic Disorder-Based Emergence in Cellular Biology in Light of the Physiological and Pathological Liquid-Liquid Phase Transitions.\",\"authors\":\"Vladimir N Uversky\",\"doi\":\"10.1146/annurev-biophys-062920-063704\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This review deals with two important concepts-protein intrinsic disorder and proteinaceous membrane-less organelles (PMLOs). The past 20 years have seen an upsurge of scientific interest in these phenomena. However, neither are new discoveries made in this century, but instead are timely reincarnations of old ideas that were mostly ignored by the scientific community for a long time. Merging these concepts in the form of the intrinsic disorder-based biological liquid-liquid phase separation provides a basis for understanding the molecular mechanisms of PMLO biogenesis.\",\"PeriodicalId\":50756,\"journal\":{\"name\":\"Annual Review of Biophysics\",\"volume\":\"50 \",\"pages\":\"135-156\"},\"PeriodicalIF\":10.4000,\"publicationDate\":\"2021-05-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"41\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annual Review of Biophysics\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1146/annurev-biophys-062920-063704\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2021/1/27 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"BIOPHYSICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annual Review of Biophysics","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1146/annurev-biophys-062920-063704","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/1/27 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"BIOPHYSICS","Score":null,"Total":0}

引用次数: 41

摘要

本文综述了蛋白内在紊乱和蛋白无膜细胞器(PMLOs)两个重要概念。在过去的20年里，科学家对这些现象的兴趣激增。然而，本世纪也没有什么新发现，而是长期以来被科学界忽视的旧思想的及时转世。将这些概念以基于内在无序的生物液-液相分离的形式结合起来，为理解PMLO生物发生的分子机制提供了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Recent Developments in the Field of Intrinsically Disordered Proteins: Intrinsic Disorder-Based Emergence in Cellular Biology in Light of the Physiological and Pathological Liquid-Liquid Phase Transitions.

This review deals with two important concepts-protein intrinsic disorder and proteinaceous membrane-less organelles (PMLOs). The past 20 years have seen an upsurge of scientific interest in these phenomena. However, neither are new discoveries made in this century, but instead are timely reincarnations of old ideas that were mostly ignored by the scientific community for a long time. Merging these concepts in the form of the intrinsic disorder-based biological liquid-liquid phase separation provides a basis for understanding the molecular mechanisms of PMLO biogenesis.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Annual Review of Biophysics 生物-生物物理

CiteScore

21.00

自引率

0.00%

发文量

期刊介绍： The Annual Review of Biophysics, in publication since 1972, covers significant developments in the field of biophysics, including macromolecular structure, function and dynamics, theoretical and computational biophysics, molecular biophysics of the cell, physical systems biology, membrane biophysics, biotechnology, nanotechnology, and emerging techniques.

期刊最新文献

Mechanisms of Inheritance of Chromatin States: From Yeast to Human. Collapse and Protein Folding: Should We Be Surprised that Biothermodynamics Works So Well? Protein Modeling with DEER Spectroscopy. Biophysical Principles Emerging from Experiments on Protein-Protein Association and Aggregation. Ancestral Reconstruction and the Evolution of Protein Energy Landscapes.