1型和2型糖尿病患者胰岛素样生长因子1与胰腺体积的关系:日本人群的横断面研究

IF 1.6 4区 医学 Q4 CELL BIOLOGY Growth Hormone & Igf Research Pub Date : 2021-08-01 DOI:10.1016/j.ghir.2021.101396
Tomoyasu Fukui , Ayako Fukase , Hiroto Sasamori , Makoto Ohara , Yusaku Mori , Michishige Terasaki , Munenori Hiromura , Hideki Kushima , Tetsuro Kobayashi , Sho-ichi Yamagishi
{"title":"1型和2型糖尿病患者胰岛素样生长因子1与胰腺体积的关系:日本人群的横断面研究","authors":"Tomoyasu Fukui ,&nbsp;Ayako Fukase ,&nbsp;Hiroto Sasamori ,&nbsp;Makoto Ohara ,&nbsp;Yusaku Mori ,&nbsp;Michishige Terasaki ,&nbsp;Munenori Hiromura ,&nbsp;Hideki Kushima ,&nbsp;Tetsuro Kobayashi ,&nbsp;Sho-ichi Yamagishi","doi":"10.1016/j.ghir.2021.101396","DOIUrl":null,"url":null,"abstract":"<div><h3>Aims/hypothesis</h3><p>Although IGF-1 is known to promote organ growth, including exocrine pancreas, the association between plasma IGF-1 levels and pancreatic size remains unclear in diabetic patients.</p></div><div><h3>Methods</h3><p><span>This cross-sectional study was designed to investigate the correlations among pancreatic volume (PV) based on computed tomography, IGF-1 levels, age- and sex-adjusted IGF-1 levels (IGF-1 </span><em>Z</em><span>-score), and C-peptide levels in patients with type 1 diabetes (T1D) (</span><em>n</em> = 51) and type 2 diabetes (T2D) (<em>n</em> = 104) in a Japanese population.</p></div><div><h3>Results</h3><p>PV was significantly correlated with body weight (BW) in both types of diabetes. PV adjusted for BW (PV/BW), IGF-1 <em>Z</em><span>-score and C-peptide levels were significantly lower in patients with T1D than T2D. There was a significant positive correlation between C-peptide levels and PV/BW in both subtypes of diabetes. IGF-1 </span><em>Z</em>-scores were significantly correlated with PV/BW in patients with T1D (<em>r</em> = 0.37, <em>P</em> = 0.007), but not T2D. Although IGF-1 <em>Z</em><span>-scores were not correlated with age, age of disease onset, disease duration, HbA1c, or C-peptide levels in both types of diabetes, a multivariable liner regression analysis revealed that IGF-1 </span><em>Z</em>-score and C-peptide levels were independent correlates of PV/BW in T1D patients, while C-peptide levels were a sole correlate in T2D.</p></div><div><h3>Conclusions/interpretation</h3><p>Decreased IGF-1 levels might be one causal factor for smaller pancreas in patients with T1D.</p></div>","PeriodicalId":12803,"journal":{"name":"Growth Hormone & Igf Research","volume":null,"pages":null},"PeriodicalIF":1.6000,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ghir.2021.101396","citationCount":"2","resultStr":"{\"title\":\"Association between insulin-like growth factor 1 and pancreatic volume in type 1 and type 2 diabetes: cross-sectional study of a Japanese population\",\"authors\":\"Tomoyasu Fukui ,&nbsp;Ayako Fukase ,&nbsp;Hiroto Sasamori ,&nbsp;Makoto Ohara ,&nbsp;Yusaku Mori ,&nbsp;Michishige Terasaki ,&nbsp;Munenori Hiromura ,&nbsp;Hideki Kushima ,&nbsp;Tetsuro Kobayashi ,&nbsp;Sho-ichi Yamagishi\",\"doi\":\"10.1016/j.ghir.2021.101396\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Aims/hypothesis</h3><p>Although IGF-1 is known to promote organ growth, including exocrine pancreas, the association between plasma IGF-1 levels and pancreatic size remains unclear in diabetic patients.</p></div><div><h3>Methods</h3><p><span>This cross-sectional study was designed to investigate the correlations among pancreatic volume (PV) based on computed tomography, IGF-1 levels, age- and sex-adjusted IGF-1 levels (IGF-1 </span><em>Z</em><span>-score), and C-peptide levels in patients with type 1 diabetes (T1D) (</span><em>n</em> = 51) and type 2 diabetes (T2D) (<em>n</em> = 104) in a Japanese population.</p></div><div><h3>Results</h3><p>PV was significantly correlated with body weight (BW) in both types of diabetes. PV adjusted for BW (PV/BW), IGF-1 <em>Z</em><span>-score and C-peptide levels were significantly lower in patients with T1D than T2D. There was a significant positive correlation between C-peptide levels and PV/BW in both subtypes of diabetes. IGF-1 </span><em>Z</em>-scores were significantly correlated with PV/BW in patients with T1D (<em>r</em> = 0.37, <em>P</em> = 0.007), but not T2D. Although IGF-1 <em>Z</em><span>-scores were not correlated with age, age of disease onset, disease duration, HbA1c, or C-peptide levels in both types of diabetes, a multivariable liner regression analysis revealed that IGF-1 </span><em>Z</em>-score and C-peptide levels were independent correlates of PV/BW in T1D patients, while C-peptide levels were a sole correlate in T2D.</p></div><div><h3>Conclusions/interpretation</h3><p>Decreased IGF-1 levels might be one causal factor for smaller pancreas in patients with T1D.</p></div>\",\"PeriodicalId\":12803,\"journal\":{\"name\":\"Growth Hormone & Igf Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2021-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.ghir.2021.101396\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Growth Hormone & Igf Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1096637421000198\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Growth Hormone & Igf Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1096637421000198","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 2

摘要

目的/假设虽然已知IGF-1促进器官生长,包括外分泌胰腺,但糖尿病患者血浆IGF-1水平与胰腺大小之间的关系尚不清楚。方法本横断面研究旨在探讨日本人群中1型糖尿病(T1D) (n = 51)和2型糖尿病(T2D) (n = 104)患者胰腺体积(PV)、IGF-1水平、年龄和性别调整的IGF-1水平(IGF-1 Z-score)和c肽水平之间的相关性。结果两型糖尿病患者的spv均与体重(BW)显著相关。T1D患者经体重调整后的PV (PV/BW)、IGF-1 Z-score和c肽水平均显著低于T2D患者。在两种糖尿病亚型中,c肽水平与PV/BW呈显著正相关。T1D患者IGF-1 z评分与PV/BW显著相关(r = 0.37, P = 0.007),而T2D患者无显著相关。虽然IGF-1 z -评分与两种糖尿病患者的年龄、发病年龄、病程、HbA1c或c肽水平无关,但多变量线性回归分析显示,IGF-1 z -评分和c肽水平是T1D患者PV/BW的独立相关因素,而c肽水平是T2D患者的唯一相关因素。结论/解释IGF-1水平降低可能是T1D患者胰腺变小的一个原因。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Association between insulin-like growth factor 1 and pancreatic volume in type 1 and type 2 diabetes: cross-sectional study of a Japanese population

Aims/hypothesis

Although IGF-1 is known to promote organ growth, including exocrine pancreas, the association between plasma IGF-1 levels and pancreatic size remains unclear in diabetic patients.

Methods

This cross-sectional study was designed to investigate the correlations among pancreatic volume (PV) based on computed tomography, IGF-1 levels, age- and sex-adjusted IGF-1 levels (IGF-1 Z-score), and C-peptide levels in patients with type 1 diabetes (T1D) (n = 51) and type 2 diabetes (T2D) (n = 104) in a Japanese population.

Results

PV was significantly correlated with body weight (BW) in both types of diabetes. PV adjusted for BW (PV/BW), IGF-1 Z-score and C-peptide levels were significantly lower in patients with T1D than T2D. There was a significant positive correlation between C-peptide levels and PV/BW in both subtypes of diabetes. IGF-1 Z-scores were significantly correlated with PV/BW in patients with T1D (r = 0.37, P = 0.007), but not T2D. Although IGF-1 Z-scores were not correlated with age, age of disease onset, disease duration, HbA1c, or C-peptide levels in both types of diabetes, a multivariable liner regression analysis revealed that IGF-1 Z-score and C-peptide levels were independent correlates of PV/BW in T1D patients, while C-peptide levels were a sole correlate in T2D.

Conclusions/interpretation

Decreased IGF-1 levels might be one causal factor for smaller pancreas in patients with T1D.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Growth Hormone & Igf Research
Growth Hormone & Igf Research 医学-内分泌学与代谢
CiteScore
3.30
自引率
0.00%
发文量
38
审稿时长
57 days
期刊介绍: Growth Hormone & IGF Research is a forum for research on the regulation of growth and metabolism in humans, animals, tissues and cells. It publishes articles on all aspects of growth-promoting and growth-inhibiting hormones and factors, with particular emphasis on insulin-like growth factors (IGFs) and growth hormone. This reflects the increasing importance of growth hormone and IGFs in clinical medicine and in the treatment of diseases.
期刊最新文献
The association between change in temporal muscle mass and treatment of acromegaly Editorial Board Medical treatment of acromegaly – When the tumor size matters: A narrative review Editorial Board Adult patients with Laron syndrome tend to develop the metabolic syndrome
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1