漫长而充实的人类遗传学职业生涯。

IF 7.7 2区 生物学 Q1 GENETICS & HEREDITY Annual review of genomics and human genetics Pub Date : 2021-08-31 Epub Date: 2021-05-04 DOI:10.1146/annurev-genom-111620-095614
Haig H Kazazian
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引用次数: 2

摘要

自20世纪60年代以来,我有幸参与了人类遗传学的惊人突破。我很幸运地在达特茅斯大学和约翰霍普金斯大学的医学院、明尼苏达大学和约翰霍普金斯大学的儿科、约翰霍普金斯大学的Barton Childs博士和国立卫生研究院的Harvey Itano博士那里接受了遗传学和分子生物学的培训。后来,约翰霍普金斯大学和宾夕法尼亚大学的合作精神对我的职业生涯很重要。在这里,我描述了人类遗传学两个不同领域的科学发现:DNA单倍型及其在解决地中海贫血分子基础中的作用,以及反转录转座子(跳跃基因)在人类生物学中的作用。我希望这篇文章可以激励其他像我一样热爱人类遗传学的人。
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A Long, Fulfilling Career in Human Genetics.

I have been fortunate and privileged to have participated in amazing breakthroughs in human genetics since the 1960s. I was lucky to have trained in medical school at Dartmouth and Johns Hopkins, in pediatrics at the University of Minnesota and Johns Hopkins, and in genetics and molecular biology with Dr. Barton Childs at Johns Hopkins and Dr. Harvey Itano at the National Institutes of Health. Later, the collaborative spirit at Johns Hopkins and the University of Pennsylvania were important to my career. Here, I describe the thrill of scientific discovery in two diverse areas of human genetics: DNA haplotypes and their role in solving the molecular basis of beta thalassemia and the role of retrotransposons (jumping genes) in human biology. I hope that this article may inspire others who love human genetics as much as I do.

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来源期刊
CiteScore
14.90
自引率
1.10%
发文量
29
期刊介绍: Since its inception in 2000, the Annual Review of Genomics and Human Genetics has been dedicated to showcasing significant developments in genomics as they pertain to human genetics and the human genome. The journal emphasizes genomic technology, genome structure and function, genetic modification, human variation and population genetics, human evolution, and various aspects of human genetic diseases, including individualized medicine.
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