合成碳水化合物为基础的HIV-1疫苗

Q1 Pharmacology, Toxicology and Pharmaceutics Drug Discovery Today: Technologies Pub Date : 2020-12-01 DOI:10.1016/j.ddtec.2020.09.004

Iñaki Bastida , Alberto Fernández-Tejada

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引用次数: 5

摘要

为了遏制艾滋病毒/艾滋病的全球流行，一种有效的预防性艾滋病毒-1疫苗至关重要。在过去的几十年里，不同的广泛中和抗体(bnAbs)的发现已经能够表征HIV包膜(Env)刺突上的几个最小表位，包括聚糖依赖片段。在此，我们简要概述了合成基于碳水化合物的表位模拟物的开发进展，这些表位模拟物用于诱导Env gp120蛋白上特定区域的bnAbs:外结构域高甘露糖簇和可变环V1V2和V3。我们重点关注最小免疫原的设计、合成和生物学评价，并讨论开发成功的HIV-1保护性疫苗的关键方面。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Synthetic carbohydrate-based HIV-1 vaccines

An effective prophylactic HIV-1 vaccine is essential in order to contain the HIV/AIDS global pandemic. The discovery of different broadly neutralizing antibodies (bnAbs) in the last decades has enabled the characterization of several minimal epitopes on the HIV envelope (Env) spike, including glycan-dependent fragments. Herein, we provide a brief overview of the progress made on the development of synthetic carbohydrate-based epitope mimics for the elicitation of bnAbs directed to certain regions on Env gp120 protein: the outer domain high-mannose cluster and the variable loops V1V2 and V3. We focus on the design, synthesis and biological evaluation of minimal immunogens and discuss key aspects towards the development of a successful protective vaccine against HIV-1.

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来源期刊

Drug Discovery Today: Technologies Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

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期刊介绍： Discovery Today: Technologies compares different technological tools and techniques used from the discovery of new drug targets through to the launch of new medicines.