对海豚和人类外周血单个核细胞的荟萃分析显示,炎症特征与暴露于高水平的全氟烷基物质有关。

Bethany J Wolf, Diane L Kamen, Patricia Fair, Gary Hardiman
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引用次数: 0

摘要

目前,关于持久性有机污染物如何影响人类,特别是那些从受污染的沿海水域食用大量海鲜的人,存在根本性的差距。迫切需要更好地了解这些污染物对沿海社区人类健康的影响。沿海海产品中污染物水平的升高会增加食用沿海海产品的人的污染物负担,鉴于这些污染物的毒性,会增加免疫系统紊乱的风险。在本文中,我们描述了我们如何使用高通量RNA测序(RNA-seq)在两种物种(海豚和人类)的外周血单个核细胞中评估污染物暴露的影响。本文提出了一种综合系统生物学方法来了解这些CECs PFAS之一对两个物种的不利影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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META-ANALYSIS OF DOLPHIN AND HUMAN PERIPHERAL BLOOD MONONUCLEAR CELLS REVEALS INFLAMMATORY SIGNATURES ASSOCIATED WITH EXPOSURE TO HIGH LEVELS OF PERFLUOROALKYL SUBSTANCES.

Currently a fundamental gap exists on how persistent organic pollutants affect humans especially those who consume high levels of seafood from contaminated coastal waters. There is an urgent need to better understand effects of these contaminants on human health in coastal communities. Elevated contaminant levels in coastal seafood will give rise to increased contaminant burdens in humans who consume coastal seafood and given the toxicity of these contaminants increase risk for immune system disorders. In this paper we describe how we assessed the effects of contaminant exposures using high-throughput RNA sequencing (RNA-seq) in peripheral blood mononuclear cells from two species, dolphins and humans. This paper presents an integrated systems biology approach to understand the adverse effects of one of these CECs PFAS on both species.

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