{"title":"阻塞性睡眠呼吸暂停对神经肌肉传递的影响--一项描述性研究。","authors":"Özgür Bilgin Topçuoğlu, Gülgün Çetintaş Afşar, Hande Alibaş, Kayıhan Uluç","doi":"10.1080/08869634.2021.1952016","DOIUrl":null,"url":null,"abstract":"<p><p><b>Objective</b>: Obstructive sleep apnea (OSA) is a sleep disorder accompanied by intermittent hypoxia. Neuromuscular transmission (NT) is known to be disturbed under chronic hypoxia. In this descriptive study, it has been aimed to test NT under intermittent hypoxia in OSA. <b>Methods</b>: Thirty-nine newly diagnosed OSA patients without any comorbidities or conditions that alter NT were included in the study. Jitter analysis was performed using a concentric needle electrode. <b>Results</b>: The mean jitter value of 39 OSA patients was 25.9 ± 3.7 μs. When compared to the mean reference jitter values, patients in the present study had significantly higher jitter (<i>p</i> < 0.001). Seven (17.9%) patients met the electrophysiological criteria for NT failure. <b>Conclusion</b>: The authors propose that intermittent hypoxia can be the trigger for NT failure in OSA. The interaction between increased oxidative stress and disturbed mitochondrial functions may also contribute.</p>","PeriodicalId":56318,"journal":{"name":"Cranio-The Journal of Craniomandibular & Sleep Practice","volume":null,"pages":null},"PeriodicalIF":2.0000,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Impact of obstructive sleep apnea on neuromuscular transmission- a descriptive study.\",\"authors\":\"Özgür Bilgin Topçuoğlu, Gülgün Çetintaş Afşar, Hande Alibaş, Kayıhan Uluç\",\"doi\":\"10.1080/08869634.2021.1952016\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Objective</b>: Obstructive sleep apnea (OSA) is a sleep disorder accompanied by intermittent hypoxia. Neuromuscular transmission (NT) is known to be disturbed under chronic hypoxia. In this descriptive study, it has been aimed to test NT under intermittent hypoxia in OSA. <b>Methods</b>: Thirty-nine newly diagnosed OSA patients without any comorbidities or conditions that alter NT were included in the study. Jitter analysis was performed using a concentric needle electrode. <b>Results</b>: The mean jitter value of 39 OSA patients was 25.9 ± 3.7 μs. When compared to the mean reference jitter values, patients in the present study had significantly higher jitter (<i>p</i> < 0.001). Seven (17.9%) patients met the electrophysiological criteria for NT failure. <b>Conclusion</b>: The authors propose that intermittent hypoxia can be the trigger for NT failure in OSA. The interaction between increased oxidative stress and disturbed mitochondrial functions may also contribute.</p>\",\"PeriodicalId\":56318,\"journal\":{\"name\":\"Cranio-The Journal of Craniomandibular & Sleep Practice\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2024-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cranio-The Journal of Craniomandibular & Sleep Practice\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/08869634.2021.1952016\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2021/7/6 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cranio-The Journal of Craniomandibular & Sleep Practice","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/08869634.2021.1952016","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/7/6 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0
摘要
目的：阻塞性睡眠呼吸暂停（OSA阻塞性睡眠呼吸暂停（OSA）是一种伴有间歇性缺氧的睡眠障碍。众所周知，神经肌肉传导（NT）在长期缺氧的情况下会受到干扰。在这项描述性研究中，目的是测试 OSA 患者在间歇性缺氧情况下的神经肌肉传导。研究方法研究对象包括 39 名新确诊的 OSA 患者，他们没有任何合并症或会改变 NT 的病症。使用同心针电极进行抖动分析。结果显示39 名 OSA 患者的平均抖动值为 25.9 ± 3.7 μs。与平均参考抖动值相比，本研究中患者的抖动明显更高（p 结论：OSA 患者的平均抖动值为 25.9 ± 3.7 μs：作者认为，间歇性缺氧可能是导致 OSA NT 功能衰竭的诱因。氧化应激增加和线粒体功能紊乱之间的相互作用也可能是原因之一。
Impact of obstructive sleep apnea on neuromuscular transmission- a descriptive study.
Objective: Obstructive sleep apnea (OSA) is a sleep disorder accompanied by intermittent hypoxia. Neuromuscular transmission (NT) is known to be disturbed under chronic hypoxia. In this descriptive study, it has been aimed to test NT under intermittent hypoxia in OSA. Methods: Thirty-nine newly diagnosed OSA patients without any comorbidities or conditions that alter NT were included in the study. Jitter analysis was performed using a concentric needle electrode. Results: The mean jitter value of 39 OSA patients was 25.9 ± 3.7 μs. When compared to the mean reference jitter values, patients in the present study had significantly higher jitter (p < 0.001). Seven (17.9%) patients met the electrophysiological criteria for NT failure. Conclusion: The authors propose that intermittent hypoxia can be the trigger for NT failure in OSA. The interaction between increased oxidative stress and disturbed mitochondrial functions may also contribute.
期刊介绍：
CRANIO: The Journal of Craniomandibular & Sleep Practice is the oldest and largest journal in the world devoted to temporomandibular disorders, and now also includes articles on all aspects of sleep medicine. The Journal is multidisciplinary in its scope, with editorial board members from all areas of medicine and dentistry, including general dentists, oral surgeons, orthopaedists, radiologists, chiropractors, professors and behavioural scientists, physical therapists, acupuncturists, osteopathic and ear, nose and throat physicians.
CRANIO publishes commendable works from outstanding researchers and clinicians in their respective fields. The multidisciplinary format allows individuals practicing with a TMD emphasis to stay abreast of related disciplines, as each issue presents multiple topics from overlapping areas of interest.
CRANIO''s current readership (thousands) is comprised primarily of dentists; however, many physicians, physical therapists, chiropractors, osteopathic physicians and other related specialists subscribe and contribute to the Journal.
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