三叶因子1通过抑制胃癌细胞tgf - β信号传导抑制上皮-间质转化。

IF 2.5 Q3 ONCOLOGY Journal of Cancer Prevention Pub Date : 2021-06-30 DOI:10.15430/JCP.2021.26.2.137
Da-Young Lee, Moon-Young Song, Eun-Hee Kim
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引用次数: 1

摘要

胃癌是世界范围内发病率高、死亡率高的恶性肿瘤。在胃癌中,上皮-间质转化(EMT)和转移进一步增加了死亡率。三叶因子1 (TFF1)已被报道为胃粘膜的保护因子。在本研究中,TFF1抑制了胃癌细胞的迁移和侵袭能力。升高的TFF1水平诱导上皮标志物E-cadherin的表达,并降低N-cadherin、vimentin、Snail、Twist、锌指E-box binding homeobox (ZEB) 1和ZEB2的表达,这是众所周知的E-cadherin表达的抑制因子。此外,基质金属蛋白酶(MMP)-2、MMP-7和MMP-9的表达被TFF1抑制,而MMP -2、MMP-7和MMP-9是肿瘤转移的主要标志物。TFF1的上调抑制了TGF-β (EMT诱导的主要信号)和TGF-β激活的Smad2/3在AGS细胞中的磷酸化。综上所述,TFF1通过抑制AGS细胞中TGF-β信号传导抑制EMT,可能用于降低这些细胞的转移潜力和侵袭性的治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Trefoil Factor 1 Suppresses Epithelial-mesenchymal Transition through Inhibition of TGF-beta Signaling in Gastric Cancer Cells.

Gastric cancer is a malignancy with high incidence and mortality worldwide. In gastric cancer, epithelial-mesenchymal transition (EMT) and metastasis further increase the mortality rate. Trefoil factor 1 (TFF1) has been reported as a protective factor in the gastric mucosa. In this study, TFF1 inhibited the migration and invasive capability of gastric cancer cells. Elevated TFF1 levels induced the expression of E-cadherin, the epithelial marker, and reduced the expression of N-cadherin, vimentin, Snail, Twist, Zinc finger E-box binding homeobox (ZEB) 1 and ZEB2, well-known repressors of E-cadherin expression. In addition, the expression of matrix metalloproteinase (MMP)-2, MMP-7 and MMP-9, which are major markers of cancer metastasis, was suppressed by TFF1. Upregulation of TFF1 inhibited TGF-β, a major signaling for EMT induction, and the phosphorylation of Smad2/3 activated by TGF-β in AGS cells. In conclusion, TFF1 inhibits EMT through suppression of TGF-β signaling in AGS cells, which might be used in therapeutic strategies for reducing metastatic potential and invasiveness of these cells.

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