卡波西肉瘤相关疱疹病毒27岁

IF 4.7 Q1 VIROLOGY Tumour Virus Research Pub Date : 2021-12-01 DOI:10.1016/j.tvr.2021.200223
Marta Maria Gaglia
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引用次数: 5

摘要

卡波西氏肉瘤相关疱疹病毒(KSHV)是27年前发现的,它与几种病理——卡波西氏肉瘤、原发性积液性淋巴瘤和多中心Castleman病的B细胞变异——之间的联系现已得到充分证实。然而,关于KSHV如何引起肿瘤仍有许多疑问。在这里,我将回顾过去几年(主要是2019-2021年)的研究,这些研究报告了关于KSHV生物学和肿瘤发生的新信息,包括与肿瘤发生有关的KSHV蛋白的新结果,KSHV相关肿瘤发展的遗传和环境变异性,以及可能成为新治疗靶点的KSHV引起的肿瘤的潜在脆弱性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Kaposi's sarcoma-associated herpesvirus at 27

Kaposi's sarcoma-associated herpesvirus (KSHV) was discovered 27 years ago and its link to several pathologies – Kaposi's sarcoma, primary effusion lymphoma, and the B cell variant of Multicentric Castleman disease – is now well established. However, many questions remain about how KSHV causes tumors. Here, I will review studies from the last few years (primarily 2019–2021) that report new information about KSHV biology and tumorigenesis, including new results about KSHV proteins implicated in tumorigenesis, genetic and environmental variability in KSHV-related tumor development, and potential vulnerabilities of KSHV-caused tumors that could be novel therapeutic targets.

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来源期刊
Tumour Virus Research
Tumour Virus Research Medicine-Infectious Diseases
CiteScore
6.50
自引率
2.30%
发文量
16
审稿时长
56 days
期刊最新文献
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