{"title":"人类疱疹病毒6型感染与慢性疲劳综合征的风险:一项系统综述和荟萃分析","authors":"Sayed-Hamidreza Mozhgani, Farid Rajabi, Mohsen Qurbani, Yousef Erfani, Somayeh Yaslianifard, Azam Moosavi, Kiomars Pourrostami, Ali Baradaran Bagheri, Alireza Soleimani, Farida Behzadian, Mahshid Safavi, Farhad Rezaei","doi":"10.1159/000517930","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Chronic fatigue syndrome (CFS) is a neurological disease that is accompanied by excessive fatigue or tiredness. There are several reports confirming the association between human herpesvirus 6 (HHV-6) infection and CFS illness. This systematic review and meta-analysis was performed to integrate the information of published studies with regard to this association until May 2021.</p><p><strong>Methods: </strong>The literature search was based on keywords including \"chronic fatigue syndrome and HHV 6,\" \"chronic fatigue syndrome and HHV-6,\" \"chronic fatigue syndrome and HHV6,\" \"chronic fatigue syndrome and Herpes virus 6,\" and \"chronic fatigue syndrome and Herpesvirus6\" in MEDLINE (PubMed), Web of Science, and EMBASE.</p><p><strong>Results: </strong>The literature search identified 17 studies to be included in the systematic review and 11 studies in meta-analysis. The symmetry funnel plot and Egger's test (p value = 0.2) identified no publication bias among studies. Moreover, the low level of I2 revealed homogeneity across studies.</p><p><strong>Discussion: </strong>In conclusion, the association between the HHV-6 infection and CFS incidence was substantiated. However, the results of this study also suggest that further comprehensive studies are needed to solidify the association between HHV-6 and CFS. Future studies should consider additional factors that may have affected the significance of such a correlation.</p>","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000517930","citationCount":"6","resultStr":"{\"title\":\"Human Herpesvirus 6 Infection and Risk of Chronic Fatigue Syndrome: A Systematic Review and Meta-Analysis.\",\"authors\":\"Sayed-Hamidreza Mozhgani, Farid Rajabi, Mohsen Qurbani, Yousef Erfani, Somayeh Yaslianifard, Azam Moosavi, Kiomars Pourrostami, Ali Baradaran Bagheri, Alireza Soleimani, Farida Behzadian, Mahshid Safavi, Farhad Rezaei\",\"doi\":\"10.1159/000517930\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Chronic fatigue syndrome (CFS) is a neurological disease that is accompanied by excessive fatigue or tiredness. There are several reports confirming the association between human herpesvirus 6 (HHV-6) infection and CFS illness. This systematic review and meta-analysis was performed to integrate the information of published studies with regard to this association until May 2021.</p><p><strong>Methods: </strong>The literature search was based on keywords including \\\"chronic fatigue syndrome and HHV 6,\\\" \\\"chronic fatigue syndrome and HHV-6,\\\" \\\"chronic fatigue syndrome and HHV6,\\\" \\\"chronic fatigue syndrome and Herpes virus 6,\\\" and \\\"chronic fatigue syndrome and Herpesvirus6\\\" in MEDLINE (PubMed), Web of Science, and EMBASE.</p><p><strong>Results: </strong>The literature search identified 17 studies to be included in the systematic review and 11 studies in meta-analysis. The symmetry funnel plot and Egger's test (p value = 0.2) identified no publication bias among studies. Moreover, the low level of I2 revealed homogeneity across studies.</p><p><strong>Discussion: </strong>In conclusion, the association between the HHV-6 infection and CFS incidence was substantiated. However, the results of this study also suggest that further comprehensive studies are needed to solidify the association between HHV-6 and CFS. Future studies should consider additional factors that may have affected the significance of such a correlation.</p>\",\"PeriodicalId\":3,\"journal\":{\"name\":\"ACS Applied Electronic Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1159/000517930\",\"citationCount\":\"6\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Electronic Materials\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1159/000517930\",\"RegionNum\":3,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2021/6/23 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, ELECTRICAL & ELECTRONIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Electronic Materials","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000517930","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/6/23 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}
引用次数: 6
摘要
慢性疲劳综合征(CFS)是一种伴有过度疲劳或疲倦的神经系统疾病。有几份报告证实了人类疱疹病毒6型(HHV-6)感染与慢性疲劳综合症之间的联系。本系统综述和荟萃分析纳入了截至2021年5月已发表的有关该关联的研究信息。方法:基于MEDLINE (PubMed)、Web of Science、EMBASE中的关键词“慢性疲劳综合征与HHV-6”、“慢性疲劳综合征与HHV-6”、“慢性疲劳综合征与HHV6”、“慢性疲劳综合征与疱疹病毒6”、“慢性疲劳综合征与疱疹病毒6”进行文献检索。结果:文献检索确定了17项研究纳入系统评价，11项研究纳入荟萃分析。对称漏斗图和Egger检验(p值= 0.2)未发现研究间存在发表偏倚。此外，低水平的I2显示了研究的同质性。讨论:总之，HHV-6感染与CFS发病率之间的关联得到了证实。然而，这项研究的结果也表明，需要进一步的全面研究来巩固HHV-6与CFS之间的联系。未来的研究应考虑可能影响这种相关性重要性的其他因素。
Human Herpesvirus 6 Infection and Risk of Chronic Fatigue Syndrome: A Systematic Review and Meta-Analysis.
Introduction: Chronic fatigue syndrome (CFS) is a neurological disease that is accompanied by excessive fatigue or tiredness. There are several reports confirming the association between human herpesvirus 6 (HHV-6) infection and CFS illness. This systematic review and meta-analysis was performed to integrate the information of published studies with regard to this association until May 2021.
Methods: The literature search was based on keywords including "chronic fatigue syndrome and HHV 6," "chronic fatigue syndrome and HHV-6," "chronic fatigue syndrome and HHV6," "chronic fatigue syndrome and Herpes virus 6," and "chronic fatigue syndrome and Herpesvirus6" in MEDLINE (PubMed), Web of Science, and EMBASE.
Results: The literature search identified 17 studies to be included in the systematic review and 11 studies in meta-analysis. The symmetry funnel plot and Egger's test (p value = 0.2) identified no publication bias among studies. Moreover, the low level of I2 revealed homogeneity across studies.
Discussion: In conclusion, the association between the HHV-6 infection and CFS incidence was substantiated. However, the results of this study also suggest that further comprehensive studies are needed to solidify the association between HHV-6 and CFS. Future studies should consider additional factors that may have affected the significance of such a correlation.
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