胡萝卜汁减少大鼠高果糖诱导的肥胖和2型糖尿病受试者的体重和BMI。

IF 2.3 Q3 NUTRITION & DIETETICS Nutrition and Metabolic Insights Pub Date : 2021-07-15 eCollection Date: 2021-01-01 DOI:10.1177/11786388211014917
Malleswarapu Mahesh, Himanshi Pandey, Mooli Raja Gopal Reddy, Prashanti Prabhakaran Sobhana, Damayanti Korrapati, Putcha Uday Kumar, Ayyalasomayajula Vajreswari, Shanmugam Murugaiha Jeyakumar
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引用次数: 5

摘要

营养干预是控制和管理非传染性疾病的一项关键战略。在这里,我们首先评估了胡萝卜汁(CJ)对喂食高果糖饮食的大鼠的一些物理和生化参数的影响,然后是2型糖尿病受试者。在动物实验中,断奶雄性Wistar大鼠被给予对照(n = 6)或高果糖(HFr;N = 24)饮食8周。然后,将HFr组大鼠再分为4组(每组6只),继续饲喂HFr饮食或转入对照组饮食,同时口服或不口服CJ (0.3 mg β-胡萝卜素),持续8周。最后,摄入CJ逆转了hfr诱导的肥胖(23±1.6 vs 18±1.1,P = 0.038),高甘油三酯血症(182±18.2 vs 90±10.5 mg/dL, PP = 0.014),同时增加了肝脏(240±38.4 vs 492±61.2µg/g, P = 0.002)和脂肪组织(1.8±0.09 vs 2.5±0.18µg/g, P = 0.026)的视黄醇水平。另一方面,在糖尿病受试者(7雄性和雌性,n = 14)与基线相比,50毫升的日常消费CJ(~ 2400µgβ-胡萝卜素)为6周显著降低体重(69.4±4.13 vs 69.0±4.09公斤,P = .014)、体重指数(27.4±1.07 vs 27.2±1.06 kg / m2, P = .007),和脂肪%(33.4±1.87 vs 31.9±2.13,P = .029)与血浆β-胡萝卜素水平(0.21±0.045 vs 0.45±0.089µmol / L, P = .044)。虽然CJ增加了血糖(145±10.4 vs 165±11.4 mg/dL, P = 0.039),但胰岛素和糖化血红蛋白水平保持不变。综上所述,胡萝卜汁的摄入逆转了大鼠模型中hfr诱导的代谢异常,并降低了糖尿病受试者的体重和BMI。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Carrot Juice Consumption Reduces High Fructose-Induced Adiposity in Rats and Body Weight and BMI in Type 2 Diabetic Subjects.

Nutritional intervention is a key strategy in the control and management of non-communicable diseases. Here, initially, we evaluated the effects of carrot juice (CJ) on some of the physical and biochemical parameters in rats fed with high-fructose diet, then in type 2 diabetic subjects. For the animal study, weanling male Wistar rats were given control (n = 6) or high fructose (HFr; n = 24) diet for 8 weeks. Then, the HFr group rats were subdivided into 4 groups (n = 6 in each) and continued either on HFr diet or shifted to control diet, with or without CJ (0.3 mg β-carotene) ingestion orally for 8 weeks. At the end, the ingestion of CJ reversed the HFr-induced adiposity (23 ± 1.6 vs 18 ± 1.1, P = .038), hypertriglyceridemia (182 ± 18.2 vs 90 ± 10.5 mg/dL, P<0.001), and hyperinsulinemia (81 ± 14.7 vs 40 ± 7.5 µU/mL, P = .014), while increased the retinol levels in liver (240 ± 38.4 vs 492 ± 61.2 µg/g, P = .002) and adipose tissue (1.8 ± 0.09 vs 2.5 ± 0.18 µg/g, P = .026). On the other hand, in the diabetic subjects (7 males and females each, n = 14) compared to their baseline, the daily consumption of 50 mL CJ (~2400 µg β-carotene) for 6 weeks significantly reduced the body weight (69.4 ± 4.13 vs 69.0 ± 4.09 kg, P = .014), BMI (27.4 ± 1.07 vs 27.2 ± 1.06 kg/m2, P = .007), and fat% (33.4 ± 1.87 vs 31.9 ± 2.13, P = .029) with an increase in plasma β-carotene levels (0.21 ± 0.045 vs 0.45 ± 0.089 µmol/L, P = .044). Although CJ increased the glucose (145 ± 10.4 vs 165 ± 11.4 mg/dL, P = .039), insulin, and glycated hemoglobin levels remained unaltered. In conclusion, the consumption of carrot juice reversed the HFr-induced metabolic abnormalities in a rat model and decreased body weight and BMI of diabetic subjects.

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来源期刊
Nutrition and Metabolic Insights
Nutrition and Metabolic Insights NUTRITION & DIETETICS-
CiteScore
3.30
自引率
0.00%
发文量
27
审稿时长
8 weeks
期刊介绍: Nutrition and Metabolic Insights is a peer-reviewed, open-access online journal focusing on all aspects of nutrition and metabolism. This encompasses nutrition, including the biochemistry of metabolism, exercise and associated physical processes and also includes clinical articles that relate to metabolism, such as obesity, lipidemias and diabetes. It includes research at the molecular, cellular and organismal levels. This journal welcomes new manuscripts for peer review on the following topics: Nutrition, including the biochemistry of metabolism, Exercise and associated physical processes, Clinical articles that relate to metabolism, such as obesity, lipidemias and diabetes, Research at the molecular, cellular and organismal levels, Other areas of interest include gene-nutrient interactions, the effects of hormones, models of metabolic function, macronutrient interactions, outcomes of changes in diet, and pathophysiology.
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