[汉坦病毒感染是斯里兰卡病因不明的慢性肾脏疾病(CKDu)的风险之一]。

Uirusu Pub Date : 2020-01-01 DOI:10.2222/jsv.70.175
Kumiko Yoshimatsu
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引用次数: 0

摘要

病因不明的慢性肾病(CKDu)自20世纪90年代以来在斯里兰卡的流行地区出现。这种病是一种慢性但致命的疾病。到目前为止,重金属和农用化学品一直被怀疑是CKDu的病因,但仍不清楚。最近,我们发现汉坦病毒在CKDu患者中有很高的血清阳性率,并报道汉坦病毒感染是CKDu的一个危险因素。汉坦病毒是啮齿动物传播的人畜共患病毒。在这里,我想介绍一个从血清流行病学到寻找宿主动物的研究故事。
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[Hantavirus infection as a risk for chronic kidney disease of unknown etiology (CKDu) in Sri Lanka].

Chronic kidney disease of unknown etiology (CKDu) has emerged in endemic areas of Sri Lanka since the 1990s. The disease is a chronic but fatal disease. Until now, heavy metals and agrochemicals have been suspected as the cause of CKDu, but it has been still unknown. Recently, we have found a high seroprevalence to hantavirus in CKDu patients and reported that hantavirus infection is a risk of CKDu. Hantaviruses are rodent-borne zoonotic viruses. Here, I would like to introduce a story of the research from sero-epidemiology to the search for host animals.

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