细菌生物膜破坏:基于噬菌体的策略与其他抗生物膜剂的最新应用综述。

IF 4.9 Q2 NANOSCIENCE & NANOTECHNOLOGY Nanotechnology, Science and Applications Pub Date : 2021-09-14 eCollection Date: 2021-01-01 DOI:10.2147/NSA.S325594
Stephen Amankwah, Kedir Abdella, Tesfaye Kassa
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引用次数: 0

摘要

生物膜是生活在生物或非生物表面的细菌群落,被细胞外聚合物物质包裹。它们在生物表面和非生物表面(包括人体组织和医疗设备表面)形成,是造成慢性感染的主要威胁。此外,目前的抗生素和杀菌剂完全清除生物膜的能力有限。在这篇综述中,作者概述了细菌生物膜的形成及其特点、负担和噬菌体的进化。此外,作者还阐明了噬菌体和噬菌体衍生酶在对付生物膜结构中的细菌方面的最新应用。从新出现的结果中可以得出结论,尽管噬菌体和噬菌体衍生产品在破坏生物膜方面取得了成功,但它们大多不足以消灭所有细菌细胞。不过,将噬菌体和/或噬菌体衍生产品与其他抗菌剂(包括抗生素、纳米粒子和抗菌肽)结合使用,可能是清除医疗器械表面生物膜和治疗人类相关感染的有效方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Bacterial Biofilm Destruction: A Focused Review On The Recent Use of Phage-Based Strategies With Other Antibiofilm Agents.

Biofilms are bacterial communities that live in association with biotic or abiotic surfaces and enclosed in an extracellular polymeric substance. Their formation on both biotic and abiotic surfaces, including human tissue and medical device surfaces, pose a major threat causing chronic infections. In addition, current antibiotics and antiseptic agents have shown limited ability to completely remove biofilms. In this review, the authors provide an overview on the formation of bacterial biofilms and its characteristics, burden and evolution with phages. Moreover, the most recent possible use of phages and phage-derived enzymes to combat bacteria in biofilm structures is elucidated. From the emerging results, it can be concluded that despite successful use of phages and phage-derived products in destroying biofilms, they are mostly not adequate to eradicate all bacterial cells. Nevertheless, a combined therapy with the use of phages and/or phage-derived products with other antimicrobial agents including antibiotics, nanoparticles, and antimicrobial peptides may be effective approaches to remove biofilms from medical device surfaces and to treat their associated infections in humans.

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来源期刊
Nanotechnology, Science and Applications
Nanotechnology, Science and Applications NANOSCIENCE & NANOTECHNOLOGY-
CiteScore
11.70
自引率
0.00%
发文量
3
审稿时长
16 weeks
期刊介绍: Nanotechnology, Science and Applications is an international, peer-reviewed, Open Access journal that focuses on the science of nanotechnology in a wide range of industrial and academic applications. The journal is characterized by the rapid reporting of reviews, original research, and application studies across all sectors, including engineering, optics, bio-medicine, cosmetics, textiles, resource sustainability and science. Applied research into nano-materials, particles, nano-structures and fabrication, diagnostics and analytics, drug delivery and toxicology constitute the primary direction of the journal.
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