伊朗南部设拉子输血中心献血者中IgA缺乏症的患病率和临床表现

IF 1.4 Q4 IMMUNOLOGY American journal of clinical and experimental immunology Pub Date : 2021-12-15 eCollection Date: 2021-01-01
Seyed Hesamedin Nabavizadeh, Mohammad Hossein Karimi, Hossein Esmaeilzadeh, Maryam Attarhoseini, Aida Askarisarvestani
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引用次数: 0

摘要

背景:IgA缺乏症是最常见的免疫缺陷疾病。大多数受影响的个体是无症状的,由于没有常规的诊断筛选程序,这种疾病的患病率仍然是不确定的。方法与材料:随机选取2017年9月至2018年3月在法尔斯输血中心就诊的7000名献血者,采用免疫比浊法检测其血清IgA水平。结果:10名献血者有选择性IgA缺乏:0.14% (CI 95%: 0.001, 0.002)。全部为男性,平均年龄36.10±9.70岁。对IgA缺乏病例常见临床表现的调查显示,研究组以复发性上呼吸道感染(50%)和过敏性疾病(40%)最为常见,明显高于对照组(p值=0.008),与对照组比较差异无统计学意义。结论:法尔斯输血中心献血者选择性IgA缺乏症(SIgAD)患病率为0.14%。SIgAD患者最常见的临床表现是复发性上呼吸道感染,其次是过敏性疾病。
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The prevalence and clinical manifestations of IgA deficiency among blood donors at transfusion centers in Shiraz, Southern Iran.

Background: IgA deficiency is the most common immunodeficiency disorder. Most affected individuals are asymptomatic, and since there are no routine diagnostic screening programs the prevalence of this disease has remained uncertain.

Methods and materials: Seven thousand blood donors who attended Fars Blood Transfusion Center, from September 2017 to March 2018, were selected randomly, and their serum IgA levels were checked by Immunoturbidimetry method. Cases with IgA levels <10 mg/dL were considered as serum IgA deficient patients. Serum IgM and IgG levels of IgA deficient cases were measured to determine selective IgA deficiency. The prevalent clinical findings of IgA deficiency were also investigated.

Results: Ten blood donors had selective IgA deficiency: 0.14% (CI 95%: 0.001, 0.002). All cases were male, with a mean age of 36.10±9.70 years. Investigating common clinical findings in the IgA deficient cases revealed the most prevalent symptoms were recurrent upper respiratory tract infections (50%) which were significantly higher in the study group compared to the control group (P-value =0.008) and allergic disorders (40%) with no statistical difference from the control cases.

Conclusion: The prevalence of selective IgA deficiency (SIgAD) among blood donors at Fars Transfusion Center was 0.14%. The most common clinical finding among the patients with SIgAD was recurrent upper respiratory infections, followed by allergic diseases.

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