急性白血病治疗期间铁超载:移植前输血经验。

International Journal of Hematologic Oncology Pub Date : 2021-11-12 eCollection Date: 2021-09-01 DOI:10.2217/ijh-2021-0005

Osman Yokus, Celalettin Herek, Tahir Alper Cinli, Hasan Goze, Istemi Serin

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引用次数: 2

摘要

背景：最近的研究表明，急性白血病和铁超负荷患者的死亡率增加。我们旨在确定急性白血病患者的铁超负荷状态。材料与方法：2015年1月至2019年12月期间被诊断为急性淋巴细胞白血病（ALL）和急性髓细胞白血病（AML）的患者被纳入研究。结果：6个月时，AML组血清铁蛋白>1000的患者比ALL组多（p=0.011）；治疗6个月后差异消失。强调铁过载是移植前发病率的重要因素是正确的，尤其是在AML病例中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Iron overload during the treatment of acute leukemia: pretransplant transfusion experience.

Background: Recent studies have shown the increased risk of mortality in cases with acute leukemia and iron overload. We aimed to determine the status of iron overload in patients with acute leukemia.

Materials & methods: Patients diagnosed with acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) between January 2015 and December 2019 were included in the study.

Results: At 6 months, there were statistically more patients with serum ferritin >1000 in the AML group compared to the ALL group (p = 0,011).

Conclusion: Iron overload occurs earlier in patients with AML; the difference disappears after 6 months of treatment. It is the correct point to emphasize that iron overload is an important factor of pretransplant morbidity, especially in AML cases.

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International Journal of Hematologic Oncology

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审稿时长

13 weeks

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