创伤后应激障碍的表观遗传学方法:在大鼠模型方面。

IF 1.2 Q4 GENETICS & HEREDITY Global Medical Genetics Pub Date : 2021-11-11 eCollection Date: 2022-03-01 DOI:10.1055/s-0041-1736633
Asli Aykac, Rasime Kalkan
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引用次数: 3

摘要

创伤后应激障碍(PTSD)是一种与压力相关的精神障碍,在暴露于危及生命的创伤经历后发展。PTSD的危险因素包括遗传因素;下丘脑-垂体-肾上腺(HPA)轴改变;神经营养系统、血清素系统、多巴胺系统和儿茶酚胺系统;以及各种各样的环境因素,如战争、事故、自然灾害、流行病、身体虐待或性虐待,这些都会给个人造成压力或创伤。为了能够了解PTSD的分子背景,研究者广泛使用啮齿动物模型。在寻找创伤后应激障碍的解决方案时,重要的是要考虑先前存在的遗传风险因素以及创伤引起的生理、分子和生化过程,这些因素可能导致对这种疾病的易感性。研究报道,表观遗传机制在受环境因素影响的生物反应以及细胞身份编程任务中发挥着重要作用。在这篇文章中,我们概述了表观遗传修饰在理解创伤后应激障碍生物学中的作用。我们还总结了动物实验的数据及其在PTSD研究中的重要性。这项研究揭示了应激和创伤后应激障碍的表观遗传背景。
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Epigenetic Approach to PTSD: In the Aspects of Rat Models.

Posttraumatic stress disorder (PTSD) is a stress-related mental disorder and develops after exposure to life-threatening traumatic experiences. The risk factors of PTSD included genetic factors; alterations in hypothalamic-pituitary-adrenal (HPA) axis; neurotrophic, serotonergic, dopaminergic, and catecholaminergic systems; and a variety of environmental factors, such as war, accident, natural disaster, pandemic, physical, or sexual abuse, that cause stress or trauma in individuals. To be able to understand the molecular background of PTSD, rodent animal models are widely used by researchers. When looking for a solution for PTSD, it is important to consider preexisting genetic risk factors and physiological, molecular, and biochemical processes caused by trauma that may cause susceptibility to this disorder. In studies, it is reported that epigenetic mechanisms play important roles in the biological response affected by environmental factors, as well as the task of programming cell identity. In this article, we provided an overview of the role of epigenetic modifications in understanding the biology of PTSD. We also summarized the data from animal studies and their importance during the investigation of PTSD. This study shed light on the epigenetic background of stress and PTSD.

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来源期刊
Global Medical Genetics
Global Medical Genetics GENETICS & HEREDITY-
自引率
11.80%
发文量
30
审稿时长
14 weeks
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