Sjögren综合征的自身抗体及其分类标准

IF 4.7 Q2 IMMUNOLOGY Journal of Translational Autoimmunity Pub Date : 2022-01-01 DOI:10.1016/j.jtauto.2021.100138
Sharon Veenbergen , Ana Kozmar , Paul L.A. van Daele , Marco W.J. Schreurs
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引用次数: 10

摘要

Sjögren综合征(SS)是一种以免疫介导的外分泌腺损伤为特征的系统性自身免疫性疾病。广泛的淋巴细胞浸润可导致腺体分泌功能的破坏和丧失。b细胞过度活跃是该疾病的一个关键特征,导致这些患者产生多种自身抗体。虽然抗ro /SSA和抗la /SSB抗体不是SS特异性的,但它们已成为疾病分类和诊断的有用生物标志物。近年来,在SS中发现了新的自身抗体。在这篇综述中,我们总结了自身抗体在Sjögren综合征分类标准中的历史作用和临床相关性,讨论了抗体检测的实验室方面,并回顾了新型自身抗体在预测疾病特定阶段、临床表型和长期并发症中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Autoantibodies in Sjögren's syndrome and its classification criteria

Sjögren's syndrome (SS) is a systemic autoimmune disease characterized by immune-mediated injury of exocrine glands. Extensive lymphocytic infiltrates may contribute to the destruction and loss of secretory function of glands. B-cell hyperactivity is a key feature of the disease resulting in the production of a diverse array of autoantibodies in these patients. Although not specific for SS, anti-Ro/SSA and anti-La/SSB antibodies have been useful biomarkers for disease classification and diagnosis. During recent years, novel autoantibodies have been discovered in SS. In this review, we summarize the historical role and clinical relevance that autoantibodies have played in the classification criteria of Sjögren's syndrome, discuss laboratory aspects in antibody detection and review the role of novel autoantibodies in predicting particular stages of the disease, clinical phenotypes and long-term complications.

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来源期刊
Journal of Translational Autoimmunity
Journal of Translational Autoimmunity Medicine-Immunology and Allergy
CiteScore
7.80
自引率
2.60%
发文量
33
审稿时长
55 days
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