{"title":"[HPLC-FLD技术测定工作环境空气中苯基(2-萘胺)浓度]。","authors":"Anna Jeżewska, Dorota Kondej","doi":"10.13075/mp.5893.01152","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Phenyl(2-naphthyl)amine (FNA) is a flammable solid with a characteristic odor. FNA is used, among others, in the production of paints and dyes, and as an antioxidant in rubber processing, lubricant for automobile engines, in brake fluids, oils, etc. In the European Union, FNA is classified as a category 2 carcinogen. In Poland, the value of the maximum admissible concentration (MAC) for FNA is 0.02 mg/m<sup>3</sup>. The aim of this study was to develop a new method for the determination of FNA, which will allow for the determination of this substance in the working environment within the concentration range of 0.1-2 of MAC value.</p><p><strong>Material and methods: </strong>The method is based on the retention of FNA on a cellulose filter, recovery of the substance with methanol and analysis of the solution thus obtained using a high-performance liquid chromatograph with a fluorescence detector.</p><p><strong>Results: </strong>The developed method enables the determination of FNA in the concentration range 2-40 μg/m<sup>3</sup>. The limit of detection (LOD) is 0.23 ng/l and the limit of quantification (LOQ) is 0.69 ng/l.</p><p><strong>Conclusions: </strong>The method complies with the requirements of the European Standard PN-EN 482 and can be used to determine FNA concentrations in the workplaces air. Med Pr. 2022;73(1):25-31.</p>","PeriodicalId":18749,"journal":{"name":"Medycyna pracy","volume":"73 1","pages":"25-31"},"PeriodicalIF":0.8000,"publicationDate":"2022-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Determination of phenyl(2-naphthyl)amine concentrations in the working environment air using HPLC-FLD technique].\",\"authors\":\"Anna Jeżewska, Dorota Kondej\",\"doi\":\"10.13075/mp.5893.01152\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Phenyl(2-naphthyl)amine (FNA) is a flammable solid with a characteristic odor. FNA is used, among others, in the production of paints and dyes, and as an antioxidant in rubber processing, lubricant for automobile engines, in brake fluids, oils, etc. In the European Union, FNA is classified as a category 2 carcinogen. In Poland, the value of the maximum admissible concentration (MAC) for FNA is 0.02 mg/m<sup>3</sup>. The aim of this study was to develop a new method for the determination of FNA, which will allow for the determination of this substance in the working environment within the concentration range of 0.1-2 of MAC value.</p><p><strong>Material and methods: </strong>The method is based on the retention of FNA on a cellulose filter, recovery of the substance with methanol and analysis of the solution thus obtained using a high-performance liquid chromatograph with a fluorescence detector.</p><p><strong>Results: </strong>The developed method enables the determination of FNA in the concentration range 2-40 μg/m<sup>3</sup>. The limit of detection (LOD) is 0.23 ng/l and the limit of quantification (LOQ) is 0.69 ng/l.</p><p><strong>Conclusions: </strong>The method complies with the requirements of the European Standard PN-EN 482 and can be used to determine FNA concentrations in the workplaces air. Med Pr. 2022;73(1):25-31.</p>\",\"PeriodicalId\":18749,\"journal\":{\"name\":\"Medycyna pracy\",\"volume\":\"73 1\",\"pages\":\"25-31\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2022-02-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medycyna pracy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.13075/mp.5893.01152\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/2/8 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medycyna pracy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.13075/mp.5893.01152","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/2/8 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
[Determination of phenyl(2-naphthyl)amine concentrations in the working environment air using HPLC-FLD technique].
Background: Phenyl(2-naphthyl)amine (FNA) is a flammable solid with a characteristic odor. FNA is used, among others, in the production of paints and dyes, and as an antioxidant in rubber processing, lubricant for automobile engines, in brake fluids, oils, etc. In the European Union, FNA is classified as a category 2 carcinogen. In Poland, the value of the maximum admissible concentration (MAC) for FNA is 0.02 mg/m3. The aim of this study was to develop a new method for the determination of FNA, which will allow for the determination of this substance in the working environment within the concentration range of 0.1-2 of MAC value.
Material and methods: The method is based on the retention of FNA on a cellulose filter, recovery of the substance with methanol and analysis of the solution thus obtained using a high-performance liquid chromatograph with a fluorescence detector.
Results: The developed method enables the determination of FNA in the concentration range 2-40 μg/m3. The limit of detection (LOD) is 0.23 ng/l and the limit of quantification (LOQ) is 0.69 ng/l.
Conclusions: The method complies with the requirements of the European Standard PN-EN 482 and can be used to determine FNA concentrations in the workplaces air. Med Pr. 2022;73(1):25-31.
期刊介绍：
The journal publishes original papers, review papers and case studies in Polish and English. The subject matter of the articles includes occupational pathology, physical, chemical and biological agents at workplace, toxicology, mutagenesis, health policy, health management, health care, epidemiology, etc.
The magazine also includes reports from national and international scientific conferences on occupational medicine. It also contains letters to the editor. Each first-in-year issue of the magazine comprises former-year indices of authors and keywords.
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