Hanna Piwowarska-Bilska, Sara Kurkowska, Bozena Birkenfeld
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Normal ranges for radiopharmaceutical uptake values were estimated based on the quantitative analysis of images acquired with a GE Healthcare NM/CT 850 gamma camera.</p><p><strong>Results: </strong>The method for healthy liver segmentation in single photon emission computed tomography/computed tomography (SPECT/CT) was optimized. The normal range of SUVs for the liver was: standardized uptake value body weight (SUVbw) max [5.2-14.0] g/mL and standardized uptake value lean body mass (SUVlbm) [3.5-9.5] g/mL. The relative standard error (relative SE) of activity concentration estimated in the phantom study for the largest hot spheres was: ϕ = 37 mm - 5.9%, ϕ = 28 mm - 7.1%, ϕ = 22 mm - 11.4%, and ϕ = 17 mm - 22%.</p><p><strong>Conclusions: </strong>Segmentation in the mid-coronal computed tomography (CT) image, at one-fourth of the height of the liver measured from the top, with a medium-sized volume of interest (VOI) outlined on a given transverse SPECT slice was regarded as the optimal method for estimating normal ranges for standardized uptake values. It is necessary to standardize quantification methods in the SPECT/CT studies. Our work is a step forward in obtaining standardization of SPECT/CT SUV calculation methods. Calculations for radiopharmaceutical uptake in tumors with volumes smaller than 5 mL are biased with a significant measurement error.</p>","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":null,"pages":null},"PeriodicalIF":0.6000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Optimized method for normal range estimation of standardized uptake values (SUVmax, SUVmean) in liver SPECT/CT images with somatostatin analog [99mTc]-HYNIC-TOC (Tektrotyd).\",\"authors\":\"Hanna Piwowarska-Bilska, Sara Kurkowska, Bozena Birkenfeld\",\"doi\":\"10.5603/NMR.a2022.0008\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>99mTc-hydrazinonicotinyl-Tyr3-octreotide ([99mTc]-HYNIC-TOC [Tektrotyd]) is a radiopharmaceutical used for the diagnosis of lesions with overexpression of somatostatin receptors. The purpose of this study was to optimize the method and estimate normal ranges for standardized uptake values of Tektrotyd in healthy livers.</p><p><strong>Material and methods: </strong>An analysis of standardized uptake value (SUVs) normal ranges was performed for images acquired in a selected \\\"healthy group\\\" of 42 patients evaluated for neuroendocrin tumors. The \\\"pathological group\\\" comprised 20 patients with liver lesions detected by scintigraphic imaging. Normal ranges for radiopharmaceutical uptake values were estimated based on the quantitative analysis of images acquired with a GE Healthcare NM/CT 850 gamma camera.</p><p><strong>Results: </strong>The method for healthy liver segmentation in single photon emission computed tomography/computed tomography (SPECT/CT) was optimized. The normal range of SUVs for the liver was: standardized uptake value body weight (SUVbw) max [5.2-14.0] g/mL and standardized uptake value lean body mass (SUVlbm) [3.5-9.5] g/mL. The relative standard error (relative SE) of activity concentration estimated in the phantom study for the largest hot spheres was: ϕ = 37 mm - 5.9%, ϕ = 28 mm - 7.1%, ϕ = 22 mm - 11.4%, and ϕ = 17 mm - 22%.</p><p><strong>Conclusions: </strong>Segmentation in the mid-coronal computed tomography (CT) image, at one-fourth of the height of the liver measured from the top, with a medium-sized volume of interest (VOI) outlined on a given transverse SPECT slice was regarded as the optimal method for estimating normal ranges for standardized uptake values. It is necessary to standardize quantification methods in the SPECT/CT studies. Our work is a step forward in obtaining standardization of SPECT/CT SUV calculation methods. 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引用次数: 2
摘要
背景:99mTc-hydrazinonicotinyl- tyr3 -octreotide ([99mTc]- hynici - toc [Tektrotyd])是一种用于诊断生长抑素受体过度表达病变的放射性药物。本研究的目的是优化方法，并估计Tektrotyd在健康肝脏中的标准摄取值的正常范围。材料和方法:对选定的42例神经内分泌肿瘤患者的“健康组”图像进行标准化摄取值(suv)正常范围的分析。病理组为20例经显像检查出肝脏病变的患者。放射性药物摄取值的正常范围是根据GE Healthcare NM/CT 850伽马相机获得的图像的定量分析来估计的。结果:优化了单光子发射计算机断层扫描/计算机断层扫描(SPECT/CT)中健康肝脏的分割方法。肝脏的suv正常范围为:标准化摄取值体重(SUVbw) max [5.2-14.0] g/mL和标准化摄取值瘦体重(SUVlbm) [3.5-9.5] g/mL。幻影研究中估计的最大热球体的活动浓度的相对标准误差(相对SE)为:φ = 37 mm - 5.9%， φ = 28 mm - 7.1%， φ = 22 mm - 11.4%，和φ = 17 mm - 22%。结论:在中冠状位计算机断层扫描(CT)图像中，从顶部测量肝脏高度的四分之一处分割，在给定的横向SPECT切片上勾画出中等大小的兴趣体积(VOI)，被认为是估计标准化摄取值正常范围的最佳方法。在SPECT/CT研究中，有必要规范定量方法。我们的工作为实现SPECT/CT SUV计算方法的标准化迈出了一步。体积小于5ml的肿瘤中放射性药物摄取的计算存在显著的测量误差。
Optimized method for normal range estimation of standardized uptake values (SUVmax, SUVmean) in liver SPECT/CT images with somatostatin analog [99mTc]-HYNIC-TOC (Tektrotyd).
Background: 99mTc-hydrazinonicotinyl-Tyr3-octreotide ([99mTc]-HYNIC-TOC [Tektrotyd]) is a radiopharmaceutical used for the diagnosis of lesions with overexpression of somatostatin receptors. The purpose of this study was to optimize the method and estimate normal ranges for standardized uptake values of Tektrotyd in healthy livers.
Material and methods: An analysis of standardized uptake value (SUVs) normal ranges was performed for images acquired in a selected "healthy group" of 42 patients evaluated for neuroendocrin tumors. The "pathological group" comprised 20 patients with liver lesions detected by scintigraphic imaging. Normal ranges for radiopharmaceutical uptake values were estimated based on the quantitative analysis of images acquired with a GE Healthcare NM/CT 850 gamma camera.
Results: The method for healthy liver segmentation in single photon emission computed tomography/computed tomography (SPECT/CT) was optimized. The normal range of SUVs for the liver was: standardized uptake value body weight (SUVbw) max [5.2-14.0] g/mL and standardized uptake value lean body mass (SUVlbm) [3.5-9.5] g/mL. The relative standard error (relative SE) of activity concentration estimated in the phantom study for the largest hot spheres was: ϕ = 37 mm - 5.9%, ϕ = 28 mm - 7.1%, ϕ = 22 mm - 11.4%, and ϕ = 17 mm - 22%.
Conclusions: Segmentation in the mid-coronal computed tomography (CT) image, at one-fourth of the height of the liver measured from the top, with a medium-sized volume of interest (VOI) outlined on a given transverse SPECT slice was regarded as the optimal method for estimating normal ranges for standardized uptake values. It is necessary to standardize quantification methods in the SPECT/CT studies. Our work is a step forward in obtaining standardization of SPECT/CT SUV calculation methods. Calculations for radiopharmaceutical uptake in tumors with volumes smaller than 5 mL are biased with a significant measurement error.
期刊介绍：
Written in English, NMR is a biannual international periodical of scientific and educational profile. It is a journal of Bulgarian, Czech, Hungarian, Macedonian, Polish, Romanian, Russian, Slovak, Ukrainian and Yugoslav Societies of Nuclear Medicine. The periodical focuses on all nuclear medicine topics (diagnostics as well as therapy), and presents original experimental scientific papers, reviews, case studies, letters also news about symposia and congresses. NMR is indexed at Index Copernicus (7.41), Scopus, EMBASE, Index Medicus/Medline, Ministry of Education 2007 (4 pts.).
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