ADAMTS生物标志物研究进展

2区医学 Q1 Chemistry Advances in Clinical Chemistry Pub Date : 2022-01-01 Epub Date: 2021-11-27 DOI:10.1016/bs.acc.2021.09.002

Rahel Schnellmann

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引用次数: 0

摘要

具有血栓反应蛋白基序的崩解素和金属蛋白酶(ADAMTS)是细胞外基质(ECM)转换的主要介质，近年来作为组织稳态和疾病发展过程中ECM重塑的主要参与者而受到越来越多的关注。虽然ADAMTS在组织重塑过程中发挥着重要作用，并且ADAMTS家族成员的功能丧失可能与许多疾病的发展有关，但对其具体底物和作用机制的了解有限。在本章中，我们将回顾目前关于ADAMTSs的知识及其作为疾病生物标志物的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Advances in ADAMTS biomarkers.

A Disintegrin and Metalloproteinase with Thrombospondin motifs (ADAMTS) are major mediators in extracellular matrix (ECM) turnover and have gained increasing interest over the last years as major players in ECM remodeling during tissue homeostasis and the development of diseases. Although, ADAMTSs are recognized in playing important roles during tissue remodeling, and loss of function in various member of the ADAMTS family could be associated with the development of numerous diseases, limited knowledge is available about their specific substrates and mechanism of action. In this chapter, we will review current knowledge about ADAMTSs and their use as disease biomarkers.

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来源期刊

Advances in Clinical Chemistry 医学-医学实验技术

CiteScore

10.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Advances in Clinical Chemistry volumes contain material by leading experts in academia and clinical laboratory science. The reviews cover a wide variety of clinical chemistry disciplines including clinical biomarker exploration, cutting edge microarray technology, proteomics and genomics. It is an indispensable resource and practical guide for practitioners of clinical chemistry, molecular diagnostics, pathology, and clinical laboratory sciences in general.