HPV16早期基因的遗传变异与LCR。现在和未来的观点。

IF 4.5 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Expert Reviews in Molecular Medicine Pub Date : 2021-12-01 DOI:10.1017/erm.2021.18
G Bletsa, F Zagouri, G D Amoutzias, M Nikolaidis, E Zografos, P Markoulatos, D Tsakogiannis
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引用次数: 8

摘要

人类乳头瘤病毒16 (HPV16)感染是宫颈发育不良的病因学因素,被认为是高度致癌物,因为它与全球50%以上的宫颈癌病例有关。HPV16的致瘤潜力引发了对病毒基因组的广泛序列分析,以确定影响病毒致癌性以及随后宫颈癌发生和进展的核苷酸变异和氨基酸替换。目前,HPV16 DNA的特异性突变与高级别鳞状上皮内病变和侵袭性宫颈癌(ICC)发展的风险增加有关,包括E6: Q14H、H78Y、L83V、Ε7: N29S、S63F、E2: H35Q、P219S、T310K、E5: I65V,而病毒DNA的高度保守区域已被广泛描述。此外,在不同地理区域的研究人群中观察到许多新的HPV16突变,因此主张不同的HPV16菌株似乎具有不同的致瘤能力。目前的综述侧重于早期基因和长控制区的变异性,强调与严重发育不良的发展特异性突变的关联。最后,它评估了HPV16 DNA的特定区域是否能够作为宫颈癌风险的有价值的生物标志物。
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Genetic variability of the HPV16 early genes and LCR. Present and future perspectives.

Human papillomavirus 16 (HPV16) infection is the aetiologic factor for the development of cervical dysplasia and is regarded as highly carcinogen, because it is implicated in more than 50% of cervical cancer cases, worldwide. The tumourigenic potential of HPV16 has triggered the extensive sequence analysis of viral genome in order to identify nucleotide variations and amino acid substitutions that influence viral oncogenicity and subsequently the initiation and progression of cervical cancer. Nowadays, specific mutations of HPV16 DNA have been associated with an increased risk of high-grade squamous intraepithelial lesions and invasive cervical cancer (ICC) development, including E6: Q14H, H78Y, L83V, Ε7: N29S, S63F, E2: H35Q, P219S, T310K, E5: I65V, whereas highly conserved regions of viral DNA have been extensively characterised. In addition, numerous novel HPV16 mutations are observed among the studied populations from various geographic regions, hence advocating that different HPV16 strains seem to emerge with different tumourigenic capacities. The present review focuses on the variability of the early genes and the long control region, emphasising on the association of specific mutations with the development of severe dysplasia. Finally, it evaluates whether specific regions of HPV16 DNA are able to serve as valuable biomarkers for cervical cancer risk.

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来源期刊
Expert Reviews in Molecular Medicine
Expert Reviews in Molecular Medicine BIOCHEMISTRY & MOLECULAR BIOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
7.40
自引率
1.60%
发文量
45
期刊介绍: Expert Reviews in Molecular Medicine is an innovative online journal featuring authoritative and timely Reviews covering gene therapy, immunotherapeutics, drug design, vaccines, genetic testing, pathogenesis, microbiology, genomics, molecular epidemiology and diagnostic techniques. We especially welcome reviews on translational aspects of molecular medicine, particularly those related to the application of new understanding of the molecular basis of disease to experimental medicine and clinical practice.
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