校准体内迷走 A、B 和 C 纤维群功能参与的阈值。

Bioelectronics in medicine Pub Date : 2018-01-01 Epub Date: 2017-11-03 DOI:10.2217/bem-2017-0001
Robin M McAllen, Anthony D Shafton, Bradford O Bratton, David Trevaks, John B Furness
{"title":"校准体内迷走 A、B 和 C 纤维群功能参与的阈值。","authors":"Robin M McAllen, Anthony D Shafton, Bradford O Bratton, David Trevaks, John B Furness","doi":"10.2217/bem-2017-0001","DOIUrl":null,"url":null,"abstract":"<p><p>Vagal nerve stimulation is widely used therapeutically but the fiber groups activated are often unknown.</p><p><strong>Aim: </strong>To establish a simple protocol to define stimulus thresholds for vagal A, B and C fibers.</p><p><strong>Methods: </strong>The intact left or right cervical vagus was stimulated with 0.1 ms pulses in spontaneously breathing anesthetized rats. Heart and respiratory rate responses to vagal stimulation were recorded. The vagus was subsequently cut distally, and mass action potentials to the same stimuli were recorded.</p><p><strong>Results: </strong>Stimulating at either 50 Hz for 2 s or 2 Hz for 10 s at experimentally determined strengths revealed A, B and C fiber thresholds that were related to respiratory and heart rate changes.</p><p><strong>Conclusion: </strong>Our simple protocol discriminates vagal A, B and C fiber thresholds <i>in vivo</i>.</p>","PeriodicalId":72364,"journal":{"name":"Bioelectronics in medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811083/pdf/bem-01-21.pdf","citationCount":"0","resultStr":"{\"title\":\"Calibration of thresholds for functional engagement of vagal A, B and C fiber groups <i>in vivo</i>.\",\"authors\":\"Robin M McAllen, Anthony D Shafton, Bradford O Bratton, David Trevaks, John B Furness\",\"doi\":\"10.2217/bem-2017-0001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Vagal nerve stimulation is widely used therapeutically but the fiber groups activated are often unknown.</p><p><strong>Aim: </strong>To establish a simple protocol to define stimulus thresholds for vagal A, B and C fibers.</p><p><strong>Methods: </strong>The intact left or right cervical vagus was stimulated with 0.1 ms pulses in spontaneously breathing anesthetized rats. Heart and respiratory rate responses to vagal stimulation were recorded. The vagus was subsequently cut distally, and mass action potentials to the same stimuli were recorded.</p><p><strong>Results: </strong>Stimulating at either 50 Hz for 2 s or 2 Hz for 10 s at experimentally determined strengths revealed A, B and C fiber thresholds that were related to respiratory and heart rate changes.</p><p><strong>Conclusion: </strong>Our simple protocol discriminates vagal A, B and C fiber thresholds <i>in vivo</i>.</p>\",\"PeriodicalId\":72364,\"journal\":{\"name\":\"Bioelectronics in medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811083/pdf/bem-01-21.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bioelectronics in medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2217/bem-2017-0001\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2017/11/3 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioelectronics in medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2217/bem-2017-0001","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2017/11/3 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

迷走神经刺激被广泛用于治疗,但所激活的纤维群往往不为人知。目的:建立一个简单的方案来确定迷走神经 A、B 和 C 纤维的刺激阈值:方法:用 0.1 毫秒脉冲刺激自主呼吸的麻醉大鼠完整的左或右颈迷走神经。记录心率和呼吸率对迷走神经刺激的反应。随后在远端切断迷走神经,记录对相同刺激的大量动作电位:结果:在实验确定的强度下,以 50 赫兹刺激 2 秒或 2 赫兹刺激 10 秒,发现 A、B 和 C 纤维阈值与呼吸和心率变化有关:结论:我们的简单方案可在体内区分迷走 A、B 和 C 纤维阈值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

摘要图片

摘要图片

摘要图片

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Calibration of thresholds for functional engagement of vagal A, B and C fiber groups in vivo.

Vagal nerve stimulation is widely used therapeutically but the fiber groups activated are often unknown.

Aim: To establish a simple protocol to define stimulus thresholds for vagal A, B and C fibers.

Methods: The intact left or right cervical vagus was stimulated with 0.1 ms pulses in spontaneously breathing anesthetized rats. Heart and respiratory rate responses to vagal stimulation were recorded. The vagus was subsequently cut distally, and mass action potentials to the same stimuli were recorded.

Results: Stimulating at either 50 Hz for 2 s or 2 Hz for 10 s at experimentally determined strengths revealed A, B and C fiber thresholds that were related to respiratory and heart rate changes.

Conclusion: Our simple protocol discriminates vagal A, B and C fiber thresholds in vivo.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Single neuron recording: progress towards high-throughput analysis. Designing a bioelectronic treatment for Type 1 diabetes: targeted parasympathetic modulation of insulin secretion. Utilizing prosthetic technology to improve quality of life: an interview with Ranu Jung and James Abbas. What directions of improvements in electrode designs should we expect in the next 5-10 years? What impact could transcutaneous vagal nerve stimulation have on an aging population?
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1