Huan Liu, Wei Huang, Jinbo Liu, Na Zhao, Hongyu Wang
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引用次数: 1
摘要
动脉硬化是否影响高血压的控制仍不完全清楚。我们假设高动脉硬化可能与不受控制的高血压有关。通过颈动脉股动脉脉搏波速度(CF-PWV)和未控制的高血压(收缩压[BP]≥130 mm Hg或舒张压≥80 mm Hg)评估动脉硬化。采用多变量调整logistic回归进行分析。2010 - 2017年共纳入1428例原发性高血压患者(平均年龄68岁,男性49.6%)。50.7%的受试者血压不受控制,CF-PWV平均水平为12.3 m/s。高血压未控制组心血管危险因素均加重,CF-PWV升高(p < 0.05)。多变量校正logistic回归分析显示,CF-PWV作为一个连续变量(奇数比[OR] 1.093, 95%可信区间[CI] 1.046 ~ 1.142)与未控制的高血压独立相关,仅次于男性(OR 1.511)和总胆固醇(OR 1.167),其次是体重指数(OR 1.092)、空腹血糖(OR 1.075)和肌酐(OR 1.010)(均p < 0.05)。作为二元变量,CF-PWV >12 m/s与未控制的高血压也独立相关(OR 1.690, 95% CI 1.320 ~ 2.164, p < 0.05)。高血压患者的动脉硬化与不受控制的血压独立相关。
Association between Arteriosclerosis and Uncontrolled Blood Pressure in Patients with Essential Hypertension: Cross-Sectional Observational Study Results of the BEST Study.
Whether arteriosclerosis can influence the hypertension control remains incompletely understood. We hypothesized that higher arteriosclerosis may be associated with uncontrolled hypertension. Arteriosclerosis was assessed by carotid femoral artery pulse wave velocity (CF-PWV) and uncontrolled hypertension (systolic blood pressure [BP] ≥130 mm Hg or diastolic BP ≥80 mm Hg). The multivariable-adjusted logistic regression was used for analysis. A total of 1,428 patients with essential hypertension (mean age 68 years, 49.6% male) were enrolled into the study from 2010 to 2017. The BP was uncontrolled in 50.7% of the participants and the mean level of CF-PWV was 12.3 m/s. All the cardiovascular risk factors were worse and CF-PWV was higher in patients with uncontrolled hypertension (all p < 0.05). Multivariable-adjusted logistic regression analysis showed that CF-PWV as a continuous variable (odd ratio [OR] 1.093, 95% confidence interval [CI] 1.046-1.142) was independently associated with uncontrolled hypertension, after male (OR 1.511) and total cholesterol (OR 1.167), followed by body mass index (OR 1.092), fasting plasma glucose (OR 1.075), and creatinine (OR 1.010) (all p < 0.05). As a binary variable, CF-PWV >12 m/s was also independently associated with uncontrolled hypertension (OR 1.690, 95% CI 1.320-2.164, p < 0.05). Arteriosclerosis is independently associated with uncontrolled BP in patients with hypertension.
期刊介绍:
The ''Journal of Vascular Research'' publishes original articles and reviews of scientific excellence in vascular and microvascular biology, physiology and pathophysiology. The scope of the journal covers a broad spectrum of vascular and lymphatic research, including vascular structure, vascular function, haemodynamics, mechanics, cell signalling, intercellular communication, growth and differentiation. JVR''s ''Vascular Update'' series regularly presents state-of-the-art reviews on hot topics in vascular biology. Manuscript processing times are, consistent with stringent review, kept as short as possible due to electronic submission. All articles are published online first, ensuring rapid publication. The ''Journal of Vascular Research'' is the official journal of the European Society for Microcirculation. A biennial prize is awarded to the authors of the best paper published in the journal over the previous two years, thus encouraging young scientists working in the exciting field of vascular biology to publish their findings.